INFLUENCE OF TIME INTERVALS ON THE DEVELOPMENT OF HEMORAGIC TRANSFORMATION IN PATIENTS WITH ACUTE ISCHEMIC STROKE

Objective. Evaluation of the influence of time intervals on the development of hemorrhagic transformation in patients with acute ischemic stroke after intravascular thromboembolectomy.

Material and methods. All patients were divided into two groups: with the development of hemorrhagic transformation (n = 68; 40.5%), average age 68.4±10.4 years old and without hemorrhagic transformation (n = 100; 59.5%), average age 66. 7±9.2 years. The correlation between the development of hemorrhagic transformation and time intervals was assessed: the time from the onset of symptoms to admission to the hospital, the time from the onset of symptoms to the start of brain multislice computed tomography, the time from admission to the hospital to the start of brain multislice computed tomography, the time from the onset of symptoms to the onset of thrombolysis, time from admission to the hospital to the start of thrombolysis, time from the onset of symptoms to arterial puncture, time from admission to the hospital to arterial puncture, time from the start of multispiral computed tomography to arterial puncture.

Results. In the studied groups, there was a direct weak correlation between the development of hemorrhagic transformation and the time to arterial puncture (coefficient r = 0.206 at p = 0.01 (from the onset of symptoms to arterial puncture), coefficient r = 0.188 at p = 0.015 (from admission to the hospital before arterial puncture), coefficient r = 0.172 at p = 0.026 (from the beginning of multislice computed tomography to arterial puncture)).

Conclusion. Analysis of time intervals allows us to understand at what stage there is a delay in time before arterial puncture, to analyze in detail the reasons and to take measures to eliminate these reasons to reduce the time before arterial puncture. Optimizing patient routing allows to shorten the time for arterial puncture, which reduces the chance of developing hemorrhagic transformation and improves treatment outcomes for patients with acute ischemic stroke.

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