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STUDYING THE EFFECTIVENESS OF STEP THERAPY WITH LEVOCARNITINE AND ACETYL-CARNITINE IN PATIENTS WITH POST-COVID ASTHENIA

Abstract

Post-Covid syndrome is one of the most common complications in patients after COVID-19. This condition affects the quality of life and contributes to the development of autonomic and cognitive disorders. Therapy for asthenic disorders should include personalized drug and non-drug treatment methods.

The purpose of this work is to assess the condition of patients after COVID-19 with post-Covid syndrome before and after stepby-step therapy with Elkar (international nonproprietary name - Levocarnitine) and Carnicetine (international nonproprietary name – Acetyl-carnitine).

Material and methods. The study involved 60 patients after COVID-19 of varying severity. They were divided into groups, the first group consisted of 30 patients who were prescribed complex therapy with Levocarnitine (10 ml intravenously/intramuscularly for 10 days) and Acetyl-carnitine (295 mg capsules, 2 capsules 2 times a day for 2 months), and the second was a control group, which also consisted of 30 patients, but they did not receive therapy. Patients were observed 14 or more days after diagnosis to determine the presence and severity of post-infectious asthenia syndrome. The level of asthenia was assessed using the Asthenic State Scale.

Results. The study found that therapy with Levocarnitine and Acetyl-carnitine not only helps to reduce the clinical manifestations of post-Covid syndrome, but also improves the general condition of the body and prevents the development of a protracted course of asthenia.

About the Authors

G. Ya. Khismatullina
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


G. R. Lurie
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


L. B. Galliamova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


References

1. Greenhalgh, T., Knight M., A'Court C. Management of post-acute covid-19 in primary care. BMJ.2020;370: m3026. (in Engl.)

2. Sudre CH [et al.] Attributes and predictors of long COVID. Nat Med 2021;27(4):626–31. (In Engl.) DOI: 10.1038/s41591-021-01292-y.

3. Melnikov K.N. [et al.]. Post-covid-19 asthenic-vegetative syndrome. Saratov Scientific and Medical Journal 2022;18 (1): 128-132. (In Russ.)

4. Rafalsky V.V. [et al.]. Experience of using the antioxidant-vitamin complex for post-Covid asthenia. Effective pharmacotherapy. 2022.;18 (26): 6-12. (In Russ.)

5. Zolotovskaia I.A. [et al.] Postcovid-19 Asthenic Syndrome. Neurosci Behav Physiol. 2022;52(2):191-195. (In Engl.)

6. Chichanovskaya, L.V., Bakhareva O.N., Sorokina K.B. A study of the efficacy and safety of l-carnitine in patients with ischemic stroke in the early rehabilitation period. Journal of Neurology and Psychiatry named after. S.S. Korsakov. Special issues. 2017;117(12 2):65 69. (In Russ.)

7. Malaguarnera M. [et al.]. L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. Am J Clin Nutr. 2007;Dec;86(6):1738-44. (In Engl.) doi: 10.1093/ajcn/86.5.1738. PMID: 18065594.

8. Sokolova L.P., Starykh E.V. Asthenic syndrome in general therapeutic practice. Journal of Neurology and Psychiatry. S.S. Korsakov. 2022;122(4):44–51. (In Russ.) https://doi.org/10.17116/jnevro202212204144

9. Bayrak S [et al.] Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity. J Int Med Res. 2020;Aug;48(8):300060520951393. (in Engl.) doi: 10.1177/0300060520951393.


Review

For citations:


Khismatullina G.Ya., Lurie G.R., Galliamova L.B. STUDYING THE EFFECTIVENESS OF STEP THERAPY WITH LEVOCARNITINE AND ACETYL-CARNITINE IN PATIENTS WITH POST-COVID ASTHENIA. Bashkortostan Medical Journal. 2024;19(3):34-38. (In Russ.)

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ISSN 1999-6209 (Print)