ANTI-LGI1-ANTIBODY AUTOIMMUNE ENCEPHALITIS (CASE REPORT AND BRIEF REVIEW)
Abstract
Anti-LGI1-Antibody Autoimmune Encephalitis (LGI-1-АE) represents one of the rare forms of limbic encephalitis, which is characterized by cognitive decline (mostly mnestic), mental problems, faciobrachial dystonic paroxysms, sometimes bilateral tonicclonic paroxysms and hyponatremia. Timely diagnosis and immunosuppressive treatment can achieve good results.
Objective. To present a typical case of LGI-1-AE in a 45-year-old woman and brief review of the literature on this disease.
Material and methods. The clinical case description contains generally accepted methods for diagnosing this disease: clinical examination, including neuropsychological evaluation, laboratory tests (blood cerebrospinal fluid), magnetic resonance imaging of the brain, electroencephalography.
Results. After a course of plasmapheresis, methylprednisolone pulse therapy and anticonvulsant treatment, the patient was discharged with improvement in the form of the absence of epileptic seizures and a slight improvement in memory for current events.
Conclusions. LGI1-AE is uncommon, and the likelihood of timely diagnosis of this disease is low. With timely treatment, the prognosis is favorable.
About the Authors
M. A. Kutlubaev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
A. R. Isanbaeva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
O. V. Lyutov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
T. R. Galiullin
ГБУЗ РБ «Республиканская клиническая больница им. Г.Г. Куватова»
Russian Federation
Russian Federation
A. Sh. Yapparova
ГБУЗ РБ «Республиканская клиническая больница им. Г.Г. Куватова»
Russian Federation
Russian Federation
M. Anant
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
S. N. Illarioshkin
ФГБНУ «Научный центр неврологии»
Russian Federation
Russian Federation
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Review
For citations:
Kutlubaev M.A., Isanbaeva A.R., Lyutov O.V., Galiullin T.R., Yapparova A.Sh., Anant M., Illarioshkin S.N. ANTI-LGI1-ANTIBODY AUTOIMMUNE ENCEPHALITIS (CASE REPORT AND BRIEF REVIEW). Bashkortostan Medical Journal. 2024;19(3):65-70. (In Russ.)
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