COMBINATIONS OF ADHESION MOLECULES, CHEMOKINS, THEIR RECEPTORS AND VASCULAR ENDOTHELIAL GROWTH FACTOR A GENE POLYMORPHISMS AS POTENTIAL PREDICTORS OF ESSENTIAL HYPERTENSION

Essential hypertension (EH) is a multifactorial disease, caused by complex interaction between genetic and environmental factors. In this study we performed an analysis of the associations between EH and polymorphic markers in candidate genes: ICAM1 rs5498 (K469E), VCAM1 rs3917010 (c.w928+420A>C), CCL2 rs1024611 (-2518A>G), CCR2 rs1799864 (V64I), CX3CR1rs3732378 (T280M), CCR5 rs333 (Δ32 I/D) and VEGFA rs35569394 (-2549(18)I/D). For genotyping we used 196 DNA samples of men with EH and 301 DNA samples of almost healthy men. Using the APSampler algorithm, combinations of polymorphic markers associated with an increased risk of developing EH have been obtained, of which the most interesting are CCL2*G/G+CCR2*I, ICAM1*E+VCAM1*C+CCR5*D +CX3CR1*M, VCAM1*A+CCR2*I+CX3CR1*M.

эссенциальная гипертензия, генетика, полиморфные маркеры генов-кандидатов, сочетания аллель- ных вариантов, алгоритм APSampler, essential hypertension, genetics, polymorphic markers of candidate genes, combinations of allelic variants, APSam- pler algorithm

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