MULTIFACTORIAL CLINICAL AND GENETIC MODEL FOR THE DEVELOPMENT OF ACUTE AND CHRONIC CALCULOUS CHOLECYSTITIS

Abstract

The article presents the results of a study of patients with chronic (ССС) and acute calculous cholecystitis (ACC). The work analyzed the relationship between the most important clinical and laboratory factors, lipid spectrum of blood serum and polymorphic loci rs693 of APOB-100 gene and rs4131229 gene ABCG5 using RОС analysis and binary logistic regression. As a result mathematical models of the probability of developing phenotypes of gallstone disease were created: P (ACC) = 1/1 + exp (-5,98+3,41*(Direct bilirubin>4 mmol/l) + 1,9*(Age > 63 years) + 2,384*(HDL ≤1.08 mmol/l) + 1,602*(LDL>1.68 mmol/l) + 1,421*(Allele C gene ABCG5) - 2,618(TG>0.74 mmol/l) + 1,291*(Cholesterol >5ммоль/l), R (CCC)= 1/1 + exp (-3,073 + 1,157*( HDL ≤1.09 mmol/l) + 1,382*( LDL>2.48 mmol/l) + 1,661*(Cholesterol >5ммоль/l)+ 0,615*(Genotype X+X - gene Apob-100). On the basis of these we created a rating scale to assess the risk of developing chronic and acute calculous cholecystitis.