Endogenous intoxication and its pathogenetic significance in hemorrhagic fever with renal syndrome
Abstract
In hemorrhagic fever with renal syndrome (HFRS), intoxication syndrome (IS), an integral part of which is endogenous intoxication, plays a major role in the pathogenesis.
Study objective. To evaluate objective criteria of IS during the infectious process depending on its severity against the background of basic therapy for HFRS.
Material and methods. 57 patients were examined: 36 with moderate and 21 with severe course. Biochemical indices and parameters of IS were studied: average mass molecules at two wavelengths, 254 and 280 nm (MCM254, MCM280), total and effective albumin concentration (TAC and ECA) with calculation of its binding capacity (ABC) and toxicity index (TI).
Results. Liver damage with the development of reactive hepatitis with cytolytic syndrome, an increase in MCM254, MCM280, IT, a decrease in TAC, ECA and ABC, which depended on the period of HFRS and were more pronounced in severe cases, were revealed. Basic therapy did not lead to the normalization of the above indicators of endogenous intoxication by the time of clinical recovery.
Conclusion. Presence of cytolytic syndrome of hepatocytes and objective laboratory criteria of IS by the time of clinical recovery will help to optimize approaches to pathogenetic therapy.
Supporting agencies: The study was conducted within the framework of the state assignment No. 056-00084-24-01, a unique registry entry number. 720000F.99.1.BN62AB46000
About the Authors
V. F. Pavelkina
Ogarev National Research Mordovian State University
Russian Federation
Russian Federation
Saransk
M. O. Krasko
Ogarev National Research Mordovian State University
Russian Federation
Russian Federation
Saransk
G. M. Khasanova
Bashkir State Medical University Ministry of Health of Russia
Russian Federation
Russian Federation
Ufa
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Review
For citations:
Pavelkina V.F., Krasko M.O., Khasanova G.M. Endogenous intoxication and its pathogenetic significance in hemorrhagic fever with renal syndrome. Bashkortostan Medical Journal. 2024;19(5):10-15. (In Russ.)
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