Angioprotector diosmin production technology

Abstract

   The objective of this study is to develop a technology for the selective extraction of hesperidin from plant material with high purity and yield, followed by its modification into diosmin.

   Material and methods. Samples of raw material (dried peels of Citrus sinensis fruits) were extracted with and without pretreatment with a CaCl₂ solution. Purification was conducted via recrystallization from dimethyl sulfoxide (DMSO). The transformation of hesperidin into diosmin was achieved by its dehydrogenation into a basic medium using crystalline iodine.

   Results. The use of calcium salts reduces the time required for extraction and produces purer hesperidin raw material at this stage as compared to raw material extraction with no processing. The content of impurities in such a product can be reduced by 2 times. The process of isolating of crude hesperidin from the mother liquor can be accelerated by heating it to 60 °C. It is more efficient to precipitate hesperidin in DMSO: water : volume ratio of components 1:1. The conditions for the reaction of converting hesperidin into diosmin were determined.

   Conclusion. The proposed technology for obtaining diosmin differs from previously suggested methods in its simplicity, high purity of the obtained extraction, and efficiency. It can be utilized for industrial production of the substance.