Preview

Bashkortostan Medical Journal

Advanced search

Structural and functional features of the heart and exercise tolerance in patients with chronic heart failure with low ejection fraction depending on body mass index

Abstract

Over time, patients with heart failure experience a significant change in the geometric parameters of the heart and a decrease in exercise tolerance.
The aim of the study. To analyze the relationship between the structural characteristics of the heart and exercise tolerance with body mass index (BMI) in patients with chronic heart failure (CHF) with low ejection fraction (EF) of left ventricle (LV).
Material and methods. Echocardioscopic phenotyping was performed in 78 patients with NYHA type II-III CHF with LV EF less than 40% (53 men and 25 women, average age 66.3±7.9 years old), as well as assessment of exercise tolerance before and after therapy.
Results. Initially, the best indicators of the structural and geometric characteristics of the left ventricle, as well as parameters of exercise tolerance, were recorded in patients with a normal BMI. Against the background of CHF therapy, the greatest positive dynamics in the form of improved structural and geometric characteristics of the heart, as well as increased exercise tolerance, was also noted in the cohort of patients with normal body weight.

About the Authors

E. B. Vakhitova
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
Russian Federation


O. M. Khromtsova
ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России
Russian Federation


References

1. Maksimova M.,S. Electrophysiological remodeling of the heart in patients with arterial hypertension. Medical alphabet. 2021;(5):26-32. (In Russ.) https://doi.org/10.33667/2078-5631-2021-5-26-32

2. D.S. Polyakov [et al.] Chronic heart failure in the Russian Federation: what has changed over 20 years of follow-up? Results of the EPOCH-CHF study. Kardiologiia. 2021;61(4):4-14. https://doi.org/10.18087/cardio.2021.4.n1628 (in Russ.)

3. G. de Simone [et al.] Cardiovascular risk in relation to a new classification of hypertensive left ventricular geometric abnormalitie. J Hypertens. 2015; 33(4):745–754. https://doi.org/10.1097/hjh.0000000000000477. (in Engl)

4. N.R. Pugliese [et al.] Classification and prognostic evaluation of left ventricular remodeling in patients with asymptomatic heart failure. Am J Cardiol. 2017; 119:71–77. https://doi.org/10.1016/j.amjcard.2016.09.018. (in Engl)

5. Ameri P. [et al.]. Medical treatment of heart failure with reduced ejection fraction: the dawn of a new era of personalized treatment? Cardiovasc Pharmacother. 2021; 7(6):539-546. https://doi.org/10.1093/ehjcvp/pvab033. PMID: 34037742. (in Engl)

6. Bahit M.C., Kochar A., Granger C.B. Post-Myocardial Infarction Heart Failure J Am Coll Cardiol HF. 2018; 6:179–186. https://doi.org/10.1016/j.jchf.2017.09.015. (in Engl)

7. Beggs S.A.S., McDonagh T.A., Gardner R.S. Chronic heart failure: epidemiology, investigation and management. Medicine. 2018;46(10):594-600. https://doi.org/10.1016/j.mpmed.2018.07.006 (in Engl)

8. Folsom A.R. [et al.] Atherosclerosis Risk in Communities Study Investigators. Absolute and attributable risks of heart failure incidence in relation to optimal risk factors. Circ Heart Fail. 2009; 1: 7-11. https://doi.org/10.1161/circheartfailure.108.794933 (in Engl)

9. He J. [et al.] Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Archives of Internal Medicine. 2001; 161(7):996-1002. https://doi.org/10.1001/archinte.161.7.996 PMID: 11295963. (in Engl)

10. Leancă S.A. [et al.] Cardiac Reverse Remodeling in Ischemic Heart Disease with Novel Therapies for Heart Failure with Reduced Ejection Fraction. Life (Basel). 2023; 13(13):1000. https://doi.org/10.3390/life13041000. (in Engl)

11. Murphy N.F. [et al.] Long-term cardiovascular consequences of obesity: 20-year follow-up of more than 15 000 middle-aged men and women (the Renfrew-Paisley study). Eur Heart J. 2006; 27(1): 96-106. https://doi.org/10.1093/eurheartj/ehi506. (in Engl)

12. Zheng Q. [et al.] Prognosis associated with geometric patterns of left ventricular remodeling: systematic review and network metaanalysis. F1000Res. 2019; 8:1130. https://doi.org/10.12688/f1000research.19907.1. (in Engl)

13. Huang B.T., Peng Y., Liu W. [et al.] Subclassification of left ventricular hypertrophy based on dilation stratifies coronary artery disease patients with distinct risk. Eur J Clin Invest. 2014;44(10):893-901. https://doi.org/10.1111/eci.12320. (in Engl)


Review

For citations:


Vakhitova E.B., Khromtsova O.M. Structural and functional features of the heart and exercise tolerance in patients with chronic heart failure with low ejection fraction depending on body mass index. Bashkortostan Medical Journal. 2025;20(1):5-10. (In Russ.)

Views: 37


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1999-6209 (Print)