Acute respiratory infections in young patients: clinical and immunological features at the present stage
Abstract
The article presents up-to-date clinical and epidemiological features of acute respiratory infection (ARI) in young patients in the Khabarovsk Territory. The study was conducted at the Federal State Budgetary Institution «301 Military Clinical Hospital of the Ministry of Defense» in Khabarovsk for the period 2019-2021.
The purpose of the study to provide a general clinical and laboratory characteristic of ARI depending on the etiology in young people.
Material and methods. A study of 120 patients (90+30) of young age (18 to 30 years old) was conducted, of which 90 people were patients with ARI of various etiologies and 30 were healthy young people. Detection of the etiology of infections was carried out by the polymerase chain reaction method in real time. The concentration of interleukins and transcription factors in the blood serum of the examined patients was determined by the enzyme immunoassay method.
Results. The maximum of chemokine levels was noted in rhinovirus and metapneumovirus infections. The IL-8 level in all ARIs was within the normal range with a tendency to decrease (P-level - 0.0005), which indicates a slow response of immune system of the macroorganism and the absence of a risk of bacterial flora overlay (P-level - 0.0005). The distribution of erythrocyte shapes relative to blood volume (RDW) tended to decrease in hospitalized patients with metapneumovirus and rhinovirus infections 12.03±1.02% (P-level - 0.0209).
Conclusion. Our study showed that ARI followed the classical development of clinical and laboratory criteria with the formation of signs of immune dysregulation in young patients. Immune dysregulation was formed due to the change of residence and the crowded location of conscripts.
About the Authors
O. A. Rychkova
ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
D. A. Sizov
ГБУЗ «Инфекционная клиническая больница №2 Департамента здравоохранения г. Москвы»
Russian Federation
Russian Federation
References
1. Ison, M.G. & Hirsch, H.H. Community-acquired respiratory viruses in transplant patients: Diversity, impact, unmet clinical needs. Clin. Microbiol. 2019;Rev. 32:e00042-e119 (in Engl).
2. Principi N., Zampiero A., Gambino M., Scala A., Senatore L., Lelii M., Ascolese B., Pelucchi C., Esposito S. Prospective evaluation of rhinovirus infection in healthy young children. J. Clin. Virol. 2015; 66:83–89. doi: 10.1016/j.jcv.2015.03.013.
3. Esneau C, Duff AC, Bartlett NW. Understanding Rhinovirus Circulation and Impact on Illness. Viruses. 2022 Jan 13;14(1):141. (in Engl) doi: 10.3390/v14010141.
4. Lee, T.I., Young, R.A.: Transcriptional regulation and its misregulation in disease. Cell 2013;152(6):1237–1251 (in Engl).
5. Stadhouders, R., Filion, G.J., and Graf, T. Transcription factors and 3D genome conformation in cell-fate decisions. Nature. 2019;569:345–354. https://doi.org/10.1038/s41586-019-1182-7.
6. Cramer, P. Organization and regulation of gene transcription. Nature. 2019;573:45–54. (in Engl) https://doi.org/10.1038/s41586-019-1517-4.
7. Consortium, E.P., [et al.]: An integrated encyclopedia of dna elements in the human genome. Nature. 2012; 57:489(7414). (in Engl)
8. Jones, Taylor & Sigauke, Rutendo & Sanford, Lynn & Taatjes, Dylan & Allen, Mary & Dowell, Robin. A transcription factor (TF) inference method that broadly measures TF activity and identifies mechanistically distinct TF networks. bioRxiv: the preprint server for biology. 2024;15(3):303. (in Engl)
9. Akdis, M., Aab, A., Altunbulakli, C., Azkur, K., Costa, R. A., Crameri, R. [et al.] Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: receptors, functions, and roles in diseases. J. Allergy Clin. Immunol. 2016;138:984–1010 (in Engl).
10. Palomo J, Dietrich D, Martin P, Palmer G and Gabay C The interleukin (IL)-1 cytokine family–Balance between agonists and antagonists in inflammatory diseases Cytokine 2015;76:25-37. (in Engl)
11. Shkaaer M T and Utba N M IL-18 Gene Polymorphisms Impacts on Its Serum Levels in Prostate Cancer Iraqi Patients Iraqi J. Sci. 2019;60:1188–96. (in Engl)
12. Al-bassam W W, Ad’hiah A H and Mayouf K Z Biomarker Significance of Interleukin-18 in Juvenile Idiopathic Arthritis Iraqi J. Sci. 2020; 61: 3200–7. (in Engl)
13. Younus, A.H., & Al-Faisal, A.H. Investigating the association between interleukin 18 and type 2 diabetes mellitus in the Iraqi population. IOP Conference Series: Earth and Environmental Science. 2024;1325(1):12-22.
14. Galaktionov V. G. Immunologija (Immunology). Moscow: Academy, 2004:520. (in Russ.).
15. Rychkova O.A. [et al.] Risk factors for severe and protracted course of acute respiratory viral infections in young patients. Infectious diseases: news, opinions, training. 2022;11(4):56-63. (in Russ.).
Review
For citations:
Rychkova O.A., Sizov D.A. Acute respiratory infections in young patients: clinical and immunological features at the present stage. Bashkortostan Medical Journal. 2025;20(1):20-25. (In Russ.)
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