Assessment of sodium concentration in urine in patients with coronavirus infection COVID-19
Abstract
Aim. To evaluate the urinary sodium concentration in COVID-19 patients with acute kidney injury.
Material and methods. The study, conducted at the Republican Clinical Infectious Diseases Hospital in Izhevsk in 2020-2021, included 52 patients with COVID-19: 24 people without clinical and laboratory signs of acute kidney injury, 14 with prerenal acute kidney injury, 14 with renal acute kidney injury. Sodium concentration in urine was determined on days 3-5 after hospitalization. The control group included 11 healthy people not infected with SARS-CoV-2.
Results. An increase in urinary sodium concentration compared to the control group was observed not only in COVID-19 patients with acute kidney injury, but also in patients with COVID-19 without signs of nephropathy (p<0.001). There were no differences in urinary sodium concentrations between the subgroups of patients with prerenal and renal acute kidney injury, as well as without overt nephropathy.
Conclusion. The diagnostic value of determining the concentration of sodium in urine for the differential diagnosis of prerenal and renal acute kidney injury in patients with COVID-19 has not been identified. An increased concentration of sodium in urine in patients with coronavirus infection without signs of acute kidney damage compared to healthy individuals may indicate the probable development of subclinical damage to the proximal tubules.
About the Authors
N. R. Yamoldinov
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
D. S. Sarksyan
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
M. V. Dudarev
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
O. G. Gileva
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Russian Federation
Russian Federation
R. T. Murzabaeva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
L. R. Akhtarova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Yamoldinov N.R., Sarksyan D.S., Dudarev M.V., Gileva O.G., Murzabaeva R.T., Akhtarova L.R. Assessment of sodium concentration in urine in patients with coronavirus infection COVID-19. Bashkortostan Medical Journal. 2025;20(1):25-30. (In Russ.)
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