Assessment of liver functional state in patients with biliary tract pathology in combination with excess body weight

The purpose of the study. To study the functional state of the liver using the iLivTouch device to assess the degree of steatosis and liver fibrosis in patients with biliary tract pathology in combination with excess body weight.
Material and methods. We have examined 48 people with chronic acalculous cholecystitis (CAC) with normal body weight (group 1), 66 people with chronic acalculous cholecystitis (CAC) and overweight (BMI) (group 2) aged 18-44 years old in accordance with clinical recommendations for diagnosis and treatment of chronic cholecystitis. The control group included 36 individuals who did not have diseases of the biliary system and were overweight. These groups were comparable by gender and age, the comparison groups were comparable by the degree of changes in the biliary system. For a comprehensive study of the functional state of liver, the iLivTouch device (Wuxi Hisky Medical Co., Ltd. (HISKY MED), China) was used to conduct transient elastography. For statistical analysis the following programs were used: Statistica, MS Excel, SPSS.
Results. During a comprehensive study of the functional state of the liver using liver elastometry, the body mass index (BMI) in the examined population was 26.1±0.3 kg/m2. The degree of liver fibrosis is 7.0±0.1 kPa (n<7.3 kPa), the degree of liver steatosis is 259.4±2.4 dB/m (n<240). According to correlation analysis, BMI, steatosis and liver fibrosis increase with age, p = 0.001; 0.002 respectively. With increasing BMI, the likelihood of developing steatosis and liver fibrosis increases, p = 0.0001. With an increase in the incidence of liver steatosis, the likelihood of developing liver fibrosis increases, p = 0.0001.
Conclusions. The data obtained indicate the need to take into account the state of liver function in CAC with BMI. The use of transient elastography helps to improve the algorithm to searching for clinical and functional disorders in patients with biliary pathology and overweight.

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