Dynamics of cytokine profile in patients with type 2 diabetes mellitus in urinary tract infection during immunocorrection

Abstract

The dynamics of cytokine content with urinary tract infection in patients with type 2 diabetes mellitus against the background of immunocorrection was studied.
Material and methods. 155 patients were divided into 5 groups. Group 1 – 35 almost healthy volunteers, Group 2 – 30 people with type 2 diabetes mellitus, Group 3 – 30 people with type 2 diabetes mellitus who received traditional basic therapy in accordance with the standards for the treatment of urinary tract infections, Group 4 – 30 people with type 2 diabetes mellitus who received the immunomodulator cycloferon along with the standard therapy, Group 5 – 30 patients with type 2 diabetes mellitus who received the immunomodulator imunofan along with the standard therapy. The main parameters studied were the content of cytokines IL-4, IL-6, IL-1β and TNF-α in the venous blood of patients in the dynamics of urinary tract infection and outside the infectious process.
Results. In patients with type 2 diabetes mellitus, the content of all the studied cytokines was increased, which indicates the presence of chronic immune inflammation in the absence of an infectious process. Against the background of basic therapy for urinary tract infections, the levels of IL-1β, TNF-α and IL-6 did not change even after 8 weeks during the resolution of the infectious process. The inclusion of imunofan in the treatment allowed us to reduce the levels of TNF-α and IL-1β, and the use of cycloferon - IL-6.
Conclusion. The results of the study indicate the advisability of including immunomodulators imunofan and cycloferon in the complex therapy of patients with type 2 diabetes mellitus and urinary tract infection.