Morphological analysis of multiple sclerosis cases with psychoorganic syndrome

Abstract

Multiple sclerosis (MS) is a demyelinating disease affecting the myelin sheath of nerve fibers. In most patients, against the background of primary damage to the white matter of the spinal cord, signs of damage to the motor system come to the fore. There is not enough information about morphological changes in the brain matter and manifestations of damage to the white matter of the hemispheres in MS.
The purpose of this study was to characterize the morphological changes in the brain substance in the clinical variant of multiple sclerosis with a predominance of psychoorganic syndrome.
Material and methods. Clinical data and results of morphological examination of the brain were analyzed in 6 cases of autopsy observations of multiple sclerosis in patients with a predominance of psychoorganic syndrome at the onset.
Results. During the study of medical records in the studied group of patients, all of them were female with an average age at the time of development of fatal complications of 53.4±3.3 years old. In the clinical picture, against the background of damage to the cerebral hemispheres, namely a decrease in intelligence, impaired concentration, exhaustion, mild changes in the motor system were noted. The study revealed extensive foci of damage at different stages. Histological examination reveals signs of vasculitis, destruction and demyelination of nerve fibers, proliferation of astrocytes near the injury, as well as destruction of interastrocytic connections.
Conclusion. The clinical variant of rapidly progressive multiple sclerosis with a predominance of psychoorganic syndrome is typical for middle-aged females with pronounced morphological stage changes in the white matter of the brain, multiple foci of demyelination against the background of progressive edema.