Indicators of antioxidant and oxidative systems in assessing the effectiveness of treatment of papulopustular rosacea patients

Abstract

Rosacea is a common chronic dermatosis affecting the central part of the face. Recently, there has been an increase in morbidity associated with the nature of the course, duration, frequent relapses, short episodes of remission and resistance to classical therapies.
Aim. To assess the effectiveness of therapy of the papulopustular rosacea using complex antioxidant and oxidative system parameters.
Material and methods. The study included 45 patients with the papulo-pustular subtype of rosacea, who were under observation at the Republican Dermatovenerologic Dispensary in Ufa. During therapy, the total antioxidant activity and total oxidative capability of blood serum were determined in patients on day 1 and on day 30 [14]. The ratios of the first indicator to the second were calculated before and on the 30th day of treatment, after which the difference between the second and first ratios was calculated. With a difference of 0.5 or more, the treatment was evaluated as effective, with a difference of less than 0.5 – as ineffective.
Results. In 35 patients, the therapy was considered effective, which correlated with the dynamics of the clinical response from the skin. For the remaining 10 patients, in whom the initial therapy regimen was considered ineffective, monitoring the indicators of the antioxidant and oxidative systems allowed timely correction of the therapy.
Conclusion. Indicators of the antioxidant and oxidative system are convenient tools for assessing the effectiveness of rosacea treatment and allow correcting irrational treatment regimens for a faster clinical response from the skin.