A Clinical Case of Interface Fluid Syndrome After Correction of Ametropia by the Clear Method
Abstract
Interface fluid syndrome is a rare complication of modern keratorefractive surgeries. Isolated cases of this syndrome after LASIK, SMILE, and keratoplasty surgeries have been reported in the literature. Features of the clinical picture may both lead to an underestimation of the intraocular pressure level and to mask diffuse lamellar keratitis. Long-term undiagnosed elevated intraocular pressure is a risk factor for glaucomatous optic neuropathy.
The article describes a clinical case of interface fluid syndrome after lenticular surgery by CLEAR technology. When complaints of decreased vision occur in patients after corneal refractive surgery, it is necessary to consider the possibility of occurrence of rare complications specific to this surgery at different times after the intervention, in particular interface fluid syndrome, which may lead to increased intraocular pressure or impaired corneal endothelial cell function.
About the Authors
E. V. TurRussian Federation
T. S. Pavlenko
Russian Federation
References
1. Iskakov I.A., Egorova Е.V. Accumulation of liquid in the flap interface (Interface fluid syndrome) as a complication after corneal refractive surgery. Fyodorov J. of Ophthalmic Surg. 2024;3(141):107-115. (in Russ).
2. Tendolkar S. [et al.] Acute interface fluid syndrome after laser in situ keratomileusis in a case of cytomegalovirus (CMV) endotheliitis and secondary glaucoma. BMJ Case Rep. 2021;14(4):e236742. (in Engl)
3. Huang Y. [et al.] Hypothyroidism affects corneal homeostasis and wound healing in mice. Exp. Eye Res. 2022;220: 109111. (in Engl)
4. Izquierdo L. Jr. [et al.] Interface fluid syndrome after descemet membrane endothelial keratoplasty in patients with history of LASIK. Cornea. 2023;42(11):1391-1394. (in Engl)
5. Goto S. [et al.] Interface fluid syndrome after laser in situ keratomileusis following herpetic keratouveitis. J. Cataract Refract. Surg. 2013;39(8):1267-1270. (in Engl)
6. Dawson D.G. [et al.] Interface fluid syndrome in human eye bank corneas after LASIK: causes and pathogenesis. Ophthalmology. 2007;114(10):1848-1859. (in Engl)
7. LoBue S. [et al.] Interface fluid syndrome masquerading as diffuse lamellar keratitis after small incision lenticule extraction. Cureus. 2023;15(3):e36832. (in Engl)
8. Jia Z. [et al.] Interface fluid syndrome: A potential lifelong complication after LASIK. A case report. Am. J. Ophthalmol. Case Rep. 2018;11: 23-25. (in Engl)
9. Kim Y.J., Kim T.G. The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness. Sci. Rep. 2021;11: 8324. (in Engl)
10. Bushley D.M. [et al.] Lamellar interface fluid accumulation following traumatic corneal perforation and laser in situ keratomileusis. J. Cataract Refract. Surg. 2005;31(6):1249-1251. (in Engl)
11. Koronis S. [et al.] Late-onset interface fluid syndrome: A case report and literature review. Semin. Ophthalmol. 2022;37(7-8): 839-848. (in Engl)
12. Lyle W.A., Jin G.J. Interface fluid associated with diffuse lamellar keratitis and epithelial ingrowth after laser in situ keratomileusis. J. Cataract. Refract. Surg. 1999;25(7):1009-1012.
13. Shajari M. [et al.] Management of interface fluid syndrome after LASIK by descemet membrane endothelial keratoplasty in a patient with Fuchs' corneal endothelial dystrophy. J. Refract. Surg. 2017;33(5):347-350. (in Engl)
14. Mansoori T. Bilateral interface fluid syndrome and glaucoma progression after laser-assisted in situ keratomileusis. Oman J. Ophthalmol. 2023;16(2):329-332. (in Engl)
15. Park H.J., Uhm K.B., Hong C.Reduction in intraocular pressure after laser in situ keratomileusis. J. of cataract and refract. surg. 2001;27:303–309. (in Engl)
16. Ramappa M. [et al.] Presumed allograft stromal rejection after deep anterior lamellar keratoplasty in a boy presenting with interface fluid syndrome. J. AAPOS. 2013;17(5):554-557. (in Engl)
17. Wheeldon C.E. [et al.] Presumed late diffuse lamellar keratitis progressing to interface fluid syndrome. J. of Cataract & Refract. Surg. 2008;34(2): 322-326. (in Engl)
18. Randleman, J.B., Shah RD.LASIK interface complications: etiology, management, and outcomes. J. Refract. Surg. 2012;28(8):575-86. (in Engl)
19. Bansal A.K. [et al.] Shifting “Ectasia”: interface fluid collection after Small Incision Lenticule Extraction (SMILE). J. of Refract. Surg. 2016;32(11):773-775. (in Engl)
20. Calleja T.M. [et al.]. Steroid-induced interface fluid syndrome after LASIK. J. of Refract. Surg. 2009;25(2):235-239. (in Engl)
Review
For citations:
Tur E.V., Pavlenko T.S. A Clinical Case of Interface Fluid Syndrome After Correction of Ametropia by the Clear Method. Bashkortostan Medical Journal. 2025;20(2):27-32. (In Russ.)