INFLUENCE OF INTERDERMAL INJECTION OF A HIGH-MOLECULAR HYALURONAN ON THE LEVEL OF SOME GROWTH FACTORS

In cosmetic and esthetic medicine injections are widely used to renew skin. One of the most physiological and safest method in injectional cosmetology is injection of native and partially stabilized hyaluronic acid (hyaluronan). However, the data, characterizing emergence of therapeutic effects at molecular level are occasional and are insufficient to understand biochemical mechanisms, being the ground for their action.The objective of the work is to study peripheral blood to determine insulinoid growth factor 1 (IGF1) and transforming growth factor - beta 1 (TGF- β1) during interdermal injection of nonstabilized high-molecular hyaluronic acid under experiment. Females of mature white rats (11-12 months) weighing 280-320 g were injected nonstabilized high-molecular hyaluronic acid three times interdermally. Immunoenzymometric analysis was used to determine growth factors in blood plasma. The medicine containing 13,5 mg/ml of hyaluronan with a molecular weight of 1 or Da was injected on the 1st, 3rd and 6th days of the experiment. The content of signal molecules was defined on the 2nd, 4th, 7th, 21st and 37th days of experience. It is established that IGF-1 increases on the 21st and 37th days, and TGF-β1 - during all periods of the research. Mechanisms of change of growth level factors and their value are discussed in the paper.

высокомолекулярная гиалуроновая кислота, интердермальное введение, инсулиноподобный ростовый фактор 1, трансформирующий ростовой фактор - бета 1, high-molecular hyaluronic acid, interdermal introduction, insulinoid growth factor 1, transforming growth factor - beta 1

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