EXPERIMENTAL STUDY OF THE EFFECT OF MORPHOLINIUM SALT OF THIAZOTIC ACID SOLUTION ON THE MORPHOGENESIS OF PERIPHERAL ENDOCRINE GLANDS
Abstract
The aim is to investigate the effect of morpholinium salt of thiazotic acid on the structure and function of the thyroid and adrenal glands in white male laboratory rats of the reproductive age.
Material and methods. The material for the study was the thyroid and adrenal glands of rats, which were intraperitoneally injected with morpholinium salt of thiazotic acid at a dose of 117,4 mg/kg for 60 days. The comparison group included rats that received an equivalent volume of saline solution. A complex of morphological, laboratory and statistical methods was used.
Results. The administration of morpholinium salt of thiazotic acid affects the structure and function of the peripheral endocrine glands, which manifests itself in a statistically significant decrease in thyroid mass by 15,40% and an increase in the mass and volume of the right adrenal gland by 9,43% and 13,27%, and the left by 12,78% and 14,98%. Macroscopic changes are confirmed by pronounced shifts in histomorphometric parameters: a decrease in the number of thyrocytes by 12,94%, the diameter of follicles by 13,49%, the colloid accumulation index by 26,93% and an increase in the height of thyrocytes by 17,18%, the cortical index by 3,12%, the width of the cortical bundle zone by 10,19%, the number of adrenocorticocytes of the bundle zone by 6,14%. The level of triiodothyronine increases by 18,79%, and cortisol by 16,71%.
Conclusion. Мorpholinium salt of thiazotic acid preserves the structural organization of thyrocytes and adrenocorticocytes by stimulating their synthetic activity.
About the Authors
K. A. Fomina
ФГБОУ ВО «Луганский государственный медицинский университет имени Святителя Луки» Минздрава России
Russian Federation
Russian Federation
K. V. Stadnik
ФГБОУ ВО «Луганский государственный медицинский университет имени Святителя Луки» Минздрава России
Russian Federation
Russian Federation
E. V. Oseledko
ФГБОУ ВО «Луганский государственный медицинский университет имени Святителя Луки» Минздрава России
Russian Federation
Russian Federation
T. V. Bocharova
ФГБОУ ВО «Луганский государственный медицинский университет имени Святителя Луки» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Fomina K.A., Stadnik K.V., Oseledko E.V., Bocharova T.V. EXPERIMENTAL STUDY OF THE EFFECT OF MORPHOLINIUM SALT OF THIAZOTIC ACID SOLUTION ON THE MORPHOGENESIS OF PERIPHERAL ENDOCRINE GLANDS. Bashkortostan Medical Journal. 2024;19(6):42-46. (In Russ.)
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