CLINICAL AND PATHOGENETIC SIGNIFICANCE OF OSTEOPONTIN IN SOMATIC AND INFECTIOUS DISEASES
Abstract
This review presents literature data on the biological effects of osteopontin (OP) as a marker reflecting the severity of the immune- inflammatory syndrome and the severity of various pathologies.
Purpose of work. To analyze the biological effects and clinical and pathogenetic significance of osteopontin in somatic and infectious diseases according to literature data.
Material and methods. A search of literature sources was conducted in the PubMed, elibrary, cyberleninka databases in order to analyze the clinical and pathogenetic significance of osteopontin in various pathologies.
Results. It follows from the literature data that osteopontin is a glycophosphoprotein that is produced by various types of cells and plays an important functional role in many biological processes in somatic and infectious diseases. An increase in the level of osteopontin in the blood at the early stages of non-infectious and infectious pathology was revealed. In the inflammatory process, osteopontin and its fragments participate in the coordination of proinflammatory and antiinflammatory reactions, influencing the secretion of interleukins 10, 12, 3, neutrophil chemotaxis, proliferation of macrophages, T-cells. It has been established that OP secreted by damaged renal tubular epithelium has a destructive effect on the alveolar epithelium during the development of renopulmonary syndrome.
Conclusion. Osteopontin may become a biomarker for early diagnosis and assessment of the severity of somatic and infectious diseases and interorgan interactions.
About the Authors
K. K. Gumerova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Россия
Россия
R. T. Murzabaeva
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Россия
Россия
D. S. Sarksyan
ФГБОУ ВО «Ижевская государственная медицинская академия» Минздрава России
Россия
Россия
D. A. Valishin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Россия
Россия
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Review
For citations:
Gumerova K.K., Murzabaeva R.T., Sarksyan D.S., Valishin D.A. CLINICAL AND PATHOGENETIC SIGNIFICANCE OF OSTEOPONTIN IN SOMATIC AND INFECTIOUS DISEASES. Bashkortostan Medical Journal. 2024;19(6):89-95. (In Russ.)
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