THE REDOX STATUS OF THE WATERY MOISTURE OF THE ANTERIOR CHAMBER OF THE EYE IN PRIMARY OPEN-ANGLE GLAUCOMA
Abstract
The review summarizes the information of the last three decades on the state of the redox system and markers of oxidative homeostasis of the aqueous humor of the anterior chamber of the eye in primary open-angle glaucoma (POAG). It is known, that the imbalance of the redox status with the formation of oxidative stress can cause the development of many eye diseases, including POAG. At the same time, highly informative biomarkers for the early diagnosis and prognosis of glaucoma have not been established at present. It is unlikely that one biomarker will be able to help in detecting glaucoma. The etiologic and pathogenetic heterogeneity of the disease will likely require the study of a number of different markers of oxidative stress for early detection and prognosis of POAG. This review presents the most informative biomarkers of oxidative stress in the aqueous humor of the anterior chamber of the eye in the context of the pathophysiology of the disease. It is expected that some of them will be useful for clinical diagnostics and monitoring of clinical responses to standard and experimental treatments.
About the Authors
E. V. Medvedeva
ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России; Краснодарский филиал ФГАУ Национальный медицинский исследовательский центр «МНТК «Микрохирургия глаза» им. акад. С.Н. Федорова» Минздрава России
Russian Federation
Russian Federation
I. M. Bykov
ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Medvedeva E.V., Bykov I.M. THE REDOX STATUS OF THE WATERY MOISTURE OF THE ANTERIOR CHAMBER OF THE EYE IN PRIMARY OPEN-ANGLE GLAUCOMA. Bashkortostan Medical Journal. 2024;19(6):110-119. (In Russ.)
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