MARKERS OF RENAL VASCULAR ENDOTHELIAL DAMAGE IN HEMORRHAGIC FEVER WITH RENAL SYNDROME COMPLICATED BY ACUTE RENAL FAILURE
Abstract
Objective. To evaluate the diagnostic and prognostic value of kidney injury markers (C-reactive protein - CRP and cystatin C) in patients with hemorrhagic fever with renal syndrome (HFRS) complicated by acute renal failure (ARF).
Material and methods. The prospective study included 336 patients with HFRS and 80 healthy volunteers. CRP and cystatin C levels were measured by immunoturbidimetric and ELISA methods.
Results. The content of CRP and cystatin C significantly increased depending on the severity of the disease, reaching a maximum with the development of ARF. The combination of markers showed high accuracy (92%) in predicting ARF. The results confirm the value of these markers for early detection and assessment of the risk of ARF, which can help improve patient management.
Conclusion. Analysis of the dynamics of CRP and cystatin C levels opens up new possibilities for optimizing diagnostics, risk stratification and personalized treatment of patients with HFRS.
About the Authors
S. Sh. Galimova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
K. S. Mochalov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
K. Sh. Galimov
ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)»
Russian Federation
Russian Federation
A. M. Nagaychenko
ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)»
Russian Federation
Russian Federation
E. F. Galimova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Galimova S.Sh., Mochalov K.S., Galimov K.Sh., Nagaychenko A.M., Galimova E.F. MARKERS OF RENAL VASCULAR ENDOTHELIAL DAMAGE IN HEMORRHAGIC FEVER WITH RENAL SYNDROME COMPLICATED BY ACUTE RENAL FAILURE. Bashkortostan Medical Journal. 2025;20(4):83-86. (In Russ.)
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