NEUROLOGICAL DISODERS AFTER INTERNAL ORGANS TRANSPLANTATION

Neurological disorders are quiet frequent, but poorly studied complications after internal organs transplantation. Their severity can vary from mild to major manifestations of nervous system disorders. In this paper we report about three patients with different neurological complications after orthotopic cadaveric liver transplantation and allograft renal transplantation. And we also consider the probable reasons for development of these complications, clinical implications, therapeutic management of patients after internal organs transplantation and prevention of neurological disorders. These patients received immunosuppressive therapy with the inclusion of tacrolimus or cyclosporine. The use of these medicines facilitates the development of infectious and toxic lesions of the nervous system, damages the blood-brain barrier (BBB), which is accompanied by vasogenic swelling of the brain. Damage to the BBB in this case is mediated through the reduced expression of glycoprotein-P, which is localized on cytoplasmic membranes of endothelial cells of histohematogenous barriers, main function of which is to create an obstacle to the absorption of xenobiotics, and in case they enter the body - their early elimination. Arisen complications are most likely associated with the development of the aforementioned pathological processes.

энцефалопатия, абсцесс головного мозга, вирусный менингоэнцефалит, трансплантация печени, трансплантация почки, такролимус, циклоспорин, encephalopathy, brain abscess, viral meningoencephalitis, liver transplantation, renal transplantation, tacrolimus, cyclosporine

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