THE RELATIONSHIP BETWEEN THE LEVELS OF VITAMIN D, RENIN AND BMI IN ADOLESCENTS WITH PRIMARY HYPERTENSION

Abstract

The article deals with one of the actual problems of paediatrics - arterial hypertension. Despite the high prevalence of the disease, the pathogenesis of hypertension is very complex and involves many aspects that require further study. At present, the inverse relationship between the concentration of vitamin D and the activity of the renin-angiotensin-aldosterone system (RAAS) has been proved.The aim of the study is to identify the relationship between the level of vitamin D, renin and body mass index in adolescents with primary arterial hypertension.The study included 87 adolescents aged 12-17 years. Patients were divided into 2 groups depending on BMI. The first group included 31 adolescents with overweight and obesity, average BMI (28.2±0.8 kg / m²). The second group consisted of 56 adolescentswith normal BMI, average BMI (21.7±1.6 kg / m²).The degree of severity of vitamin D deficiency in children with primary hypertension and overweight (15.0±1.0 ng / ml) is greater than in children with hypertension and normal body weight (18.1±1.1ng / ml) p = 0.03.The level of renin in the first group with increased BMI (66.5±6.3 pg / ml) is more pronounced than in children of the second group with normal BMI(57.1±4.9 pg / ml) p = 0.04.So, the presence of inverse relationship between the vitamin D content and plasma renin activity in patients with hypertensionhas been proven, as well as the more pronounced prevalence of vitamin D deficiency in obese patients.