IMMUNOLOGICAL PECULIARITIES OF THE INFLAMMATORY PROCESS IN THE ACUTE PERIOD OF IXODIC TICK-BORNE BORRELIOSIS

Abstract

The article presents the results of studying the production of serum cytokines in patients with tick-borne borreliosis (ICB). During eruptive phase of the disease the level of serum anti-inflammatory cytokines (TNF-α, IL-6, IL-8, IL-18) significantly increases In the dynamics of the disease, the blood concentration of TNF-α is significantly reduced, however, by the recovery period normalization of the average values of TNF-α does not occur. IL-6 content in the serum by the period of the reverse development of symptoms significantly increases, but in the period of early convalescence it decreases almost by half, and reaches the values of the control group by three months after discharge. In the dynamics of the disease, the concentration in the blood of IL-8 decreases. At the same time, the trend towards normalization of IL-8 was observed in both groups, but at medium severity it was more pronounced. The content of anti-inflammatory cytokine (IL-10) gradually rises and reaches its peak to the period of the reverse development of symptoms, then decreases slowly and remains statistically significantly high after 3 months and reaches the norm after 6 months of dispensary observation.