MIR-25 IS UP-REGULATED IN OVARIAN CANCER AND PROMOTES CELL PROLIFERATION AND MOTILITY
Abstract
Ovarian cancer (OC) is a major cancer-related mortality among women. Recent studies showed that many microRNAs (miRNAs) were dysregulated and involved in tumorigenesis of OC. The present study investigated the role of miR-25 in the development and progression of OC. The expression of miR-25 was increased in OC tissues and cell lines. Inhibition of miR-25 remarkably suppressed proliferation, migration, and invasion of OC cells. Large tumor suppressor 2 (LATS2), a tumor suppressor, was confirmed to be a direct target of miR-25 in OC cells. Moreover, restoration of LATS2 significantly attenuated the oncogenic effects of miR-25. Together, our data suggest an oncogenic role of miR-25 in OC, and a potentially novel diagnostic and therapeutic target for OC treatment.
Keywords
ovarian cancer,
miR-25,
proliferation,
migration,
invasion,
рак яичника,
miR-25,
пролиферация,
миграция,
инвазия
About the Authors
Feng Shujun
Harbin Medical University, Harbin
Russian Federation
Russian Federation
Pan Wenjing
Harbin Medical University, Harbin
Russian Federation
Russian Federation
Jin Ye
Harbin Medical University, Harbin
Russian Federation
Russian Federation
S. Kapora Elena
Bashkir State Medical University
Russian Federation
Russian Federation
Zheng Jianhua
Harbin Medical University, Harbin
Russian Federation
Russian Federation
V. Sakhautdinova Indira
Bashkir State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Shujun F., Wenjing P., Ye J., Elena S.K., Jianhua Zh., Indira V.S. MIR-25 IS UP-REGULATED IN OVARIAN CANCER AND PROMOTES CELL PROLIFERATION AND MOTILITY. Bashkortostan Medical Journal. 2017;12(5):90-94. (In Russ.)
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