A SUPPRESSOR LINE-1: PROTECTS CANCER CELL FROM THE DRUG
Abstract
The maintenance of phenotypic heterogeneity in the cell population is a mechanism of evolutionary conservatism, which is a mechanism for population survival stress exposure. The researchers found that the genome of the cancer cell subpopulation survived the next one when using other lethal drugs (DTPS) and showed a suppressed chromatin state characterized by histone H3 lysine 9 and 27 (H3K9 and H3K27) increasing degree of methylation.
Keywords
Line-1,
сancer,
heterogeneity,
drug resistance,
LINE-1,
рак,
гетерогенность,
лекарственная устойчивость
About the Authors
D. A. Magafurov
Second Affiliated Hospital of Harbin Medical University; Neuroscience Institute, Heilongjiang Academy of Medical Sciences; Neuroscience Institute, Sino-Russian Medical Research Center; Bashkir State Medical University
Russian Federation
Russian Federation
Wu Pengfei
Second Affiliated Hospital of Harbin Medical University; Neuroscience Institute, Heilongjiang Academy of Medical Sciences; Neuroscience Institute, Sino-Russian Medical Research Center
Russian Federation
Russian Federation
Cai Jinquan
Second Affiliated Hospital of Harbin Medical University; Neuroscience Institute, Heilongjiang Academy of Medical Sciences; Neuroscience Institute, Sino-Russian Medical Research Center
Russian Federation
Russian Federation
S. M. Safin
Bashkir State Medical University
Russian Federation
Russian Federation
Jiang Chuanlu
Second Affiliated Hospital of Harbin Medical University; Neuroscience Institute, Heilongjiang Academy of Medical Sciences; Neuroscience Institute, Sino-Russian Medical Research Center
Russian Federation
Russian Federation
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Review
For citations:
Magafurov D.A., Pengfei W., Jinquan C., Safin S.M., Chuanlu J. A SUPPRESSOR LINE-1: PROTECTS CANCER CELL FROM THE DRUG. Bashkortostan Medical Journal. 2017;12(5):100-102. (In Russ.)
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