OSTEOPOROSIS RISK FACTORS AND BODY WEIGHT INCREASE IN PATIENTS WITH UROLITHIASIS

The results of the conducted epidemiological research revealed the connection between urolithiasis and cardiovascular diseases, chronic kidney disease, diabetes and metabolic syndrome.Development, progressing and recurrence of urolithiasis depend on many reasons, one of which is the state of calcium ex-change, because it’s the main element, making up the calculus.The study aimed to reveal the risk factors for osteoporosis development and clinical manifestations of metabolic syndrome in patients with urolithiasis.The study included 44 patients with urolithiasis. Risk factors were assessed using questionnaire, clinical examination included waist circumference measurement, determination of BMI and daily calciuria.Risk factors for osteoporosis development were revealed in 20 (45.5%) of patients with urolithiasis. These risk factors prevailedin patients with BMI 25 kg/m2 and more (р=0,0937), as well as waist circumference being 80 cm and more (p=0.022).Thus, the results of analysis of osteoporosis risk factors, clinical manifestations of metabolic syndrome, indices of daily calciuria in patients with urolithiasis proved the existence of pathogenetic connection of osteoporosis, metabolic syndrome and urolithiasis.

мочекаменная болезнь, рецидив, остеопороз, индекс массы тела, метаболический синдром, urolithiasis, recurrence, osteoporosis, BMI, metabolic syndrome

1. Аполихин О.И. Мочекаменная болезнь как новый компонент метаболического синдрома / О.И. Аполихин [и др.]// Саратовский научно-медицинский журнал. - 2011. - № 2. - С. 117

2. Лесняк, О. М. Остеопороз. Диагностика, профилактика и лечение / О.М. Лесняк, Л.И. Беневоленская. - М.: ГЭОТАР-Медиа, 2012. - 176 с

3. Мкртумян А.М. Особенности минерального обмена и костной системы при некоторых эндокринных заболеваниях: автореф. дисс... д-ра мед. наук. - М., 2000. - 43 с

4. Таганович, А. Д. Патологическая биохимия / А.Д. Таганович, Э.И. Олецкий, И.Л. Котович. - М.: БИНОМ, 2016. - 448 c

5. Correlation of metabolic syndrome with urinary stone composition / ST Cho [et al.] // Int J Urol. - 2013. - Vol.20, N 2. - P.208-213

6. Etiopathogenic factors of the different types of urinary litiasis / M. Arrabal-Martín [et al.] // Arch Esp Urol. - 2017. - Vol. 70(1). - P. 40-50

7. Risk of renal stone formation induced by long-term bed rest could be decreased by premedication with bisphosphonate and increased by resistive exercise / A. Okada [et al.]// Int J Urol. - 2008. - Vol. 15, N. 7. - P. 630-635

8. Pathophysiology-based treatment of urolithiasis / T. Yasui [et al.]// Int J Urol. - 2017. - Vol. 24(1). - P. 32-38

9. Metabolic syndrome contributes to renal injury mediated by hyperoxaluria in a murine model of nephrolithiasis / J. Sáenz-Medina [et al.] // Urolithiasis. - 2017. https://doi.org/10.1007/s00240-017-0979-9

10. Role of IBM on litogenic risk in women with idiopathic calcium nephrolitiasis and controls / A. Nouvenne [et al.] // Urol. Research. - 2008. - Vol. 36, N. 3-4. - P.223

11. MedCalc Statistical Software version 17.0.4 (MedCalc Software bvba, Ostend, Belgium, https://www.medcalc.org и 2017)

12. Lindsay R. Дефицит эстрогенов. / Л. Джозеф Мелтон III Б. Лоренс Риггз. Остеопороз. - М.: Бином, Hевский диалект, 2000. - 560 c

13. Urinary lithiasis as a systemic disease / M Leanez Jiménez [et al.]// Arch Esp Urol. - 2017. - Vol. Jan;70(1). - P. 28-39

14. Schwaderer, A.L. Urinary stone disease in pediatric and adult metabolic bone clinic patients / A.L. Schwaderer, A. Oduguwa, K. Kusumi // Urolithiasis. - 2017 - Mar 8. doi: 10.1007/s00240-017-0968-z