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POTENTIAL OF LONG NON-CODING RNAS IN DIAGNOSIS OF ONCOLOGICAL DISEASES IN GENERAL AND CERVICAL CANCER IN PARTICULAR

Abstract

Cervical cancer ranks first among oncological diseases of female reproductive system. Most studies of the last decade are devoted to the problem of early diagnosis and prediction of tumor process. One of the promising biomarkers of tumor progression are long non-coding RNAs, known as key regulators of the majority of intracellular processes. This review considers the perspective of searching new long non-coding RNAs and the use of their potential in diagnosis of oncological diseases in general and cervical cancer in particular.

About the Authors

I. V. Sakhautdinova
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


E. S. Kapora
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation


References

1. Всемирная организация здравоохранения: информационный бюллетень № 297 Февраль 2017 г. [Электронный ресурс] // URL: http://who.int/mediacentre/factsheets/fs297/ru/ (Дата обращения 25.08.2017)

2. Выявление злокачественных новообразований молочной железы и органов женской репродуктивной системы при диспансеризации определенных групп взрослого населения / Л.М. Александрова [и др.] // Профилактическая медицина. - 2016. - Т.19, №3. - С.4-11

3. Прогностическое значение теста на ДНК вируса папилломы человека при хирургическом лечении плоскоклеточного рака шейки матки / Е. В. Бахидзе [и др.] // Вопросы онкологии. - 2012. - Т. 58, № 2. - С. 233-237

4. Роль длинных некодирующих РНКвпроцессе канцерогенеза / Н. А. Лисицын [и др.] // Молекулярная биология. - 2015. - Т.49, №4. - С.561-570

5. Decreased expression of lncrna gas5 predicts a poor prognosis in cervical cancer / S Cao [et al.] // Int J Clin Exp Pathol. - 2014. - Vol. 7. - P. 6776-83

6. Decreased expression of lncrna gas5 predicts a poor prognosis in cervical cancer / S Cao [et al.] // Int J Clin Exp Pathol. - 2014. - Vol. 7. - P. 6776-83. Low expression of long noncoding xloc_010588 indicates a poor prognosis and promotes proliferation through upregulation of c-myc in cervical cancer / LM Liao [et al.] // Gynecol Oncol. - 2014. - Vol.133. - P. 616-623

7. ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome // Nature. - 2012. - Vol. 489. - P. 57-74

8. Landscape of transcription in human cells / S. Djebali [et al.] // Nature. - 2012. - Vol. 489. - P. 101-108

9. Identification of the long non-coding rna pou3f3 in plasma as a novel biomarker for diagnosis of esophageal squamous cell carcinoma / YS Tong [et al.] // Mol Cancer. - 2015. - Vol. 14. - P. 3

10. Characterization of HULC, a novel gene with striking up-regulation in hepatocellular carcinoma, as noncoding RNA / K. Panzitt [et al.] // Gastroenterology. - 2007. - Vol. 132. - P. 330-342

11. Shappell, S. B. Clinical utility of prostate carcinoma molecular diagnostic tests / S. B. Shappell // Reviews in Urology. - 2008. - Vol. 10, No. 1. - P. 44-69

12. Non-coding RNAs in cancer diagnosis and therapy / M. Rasool [et al.] // Non-coding RNA Research. - 2016. - Vol. 1, No. 1. - P. 69-76

13. Circulating long non-coding RNAs in plasma of patients with gastric cancer / T. Arita [et al.] // Anticancer Research. - 2013. - Vol. 33, No. 8. - P. 3185-3193

14. Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer / X. Zhou [et al.] // Scien- tific Reports. - 2015. - Vol. 5, article 11516

15. Jiang, S. Low expression of long non-coding rna let inhibits carcinogenesis of cervical cancer / S. Jiang, HL. Wang, J.Yang // Int J Clin Exp Pathol. - 2015. - Vol. 8. - P. 806-811

16. High MALAT1 expression predicts a poor prognosis of cervical cancer and promotes cancer cell growth and invasion / L. Yang [et al.] // European Review for Medical and Pharmacological Sciences. - 2015. - Vol. 19. - P. 3187-3193

17. Chen, X. Up-regulation of long non-coding RNA CCAT2 correlates with tumor metastasis and poor prognosis in cervical squamous cell cancer patients / X. Chen, L. Liu, W. Zhu // Int J Clin Exp Pathol. - 2015. - Vol. 8. - P. 13261-13266


Review

For citations:


Sakhautdinova I.V., Kapora E.S. POTENTIAL OF LONG NON-CODING RNAS IN DIAGNOSIS OF ONCOLOGICAL DISEASES IN GENERAL AND CERVICAL CANCER IN PARTICULAR. Bashkortostan Medical Journal. 2017;12(5):127-131. (In Russ.)

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ISSN 1999-6209 (Print)