POSTTRANSPLANTATION DISODERS OF THE NERVOUS SYSTEM

Organs transplantation is a method of choice in the treatment of many acute and chronic diseases in their final stage, as well as in some cases of primary malignant neoplasms. With the increase in the number of operations performed, data on a variety of complications of these interventions, including neurological ones, began to accumulate.Patients, who underwent transplantation of internal organs, are forced to be on immunosuppressive therapy. It includes the appointment of glucocorticoids (prednisolone or methylprednisolone), inhibitors of calcineurin (cyclosporine A or tacrolimus), inhibitors of inosine monophosphate dehydrogenase (mycophenolate mofetil or mycophenolic acid). The severity of neurological disorders can range from mild (headache, dizziness, paresthesia, dysesthesia, tremor, sleep disturbance, photophobia) to extremely severe manifestations (mental confusion, seizures, cortical blindness, encephalopathy and coma). Typically, these symptoms occur soon after transplantation. Most likely, the neurotoxic effect of drugs develops against the background of intensive therapy with immunosuppressants and has a significant impact on the survival and life quality of patients.

нейропатия, синдром обратимой задней лейкоэнцефалопатии, центральный понтинный миелинолиз, абсцесс головного мозга, вирусный менингоэнцефалит, трансплантация, такролимус, neuropathy, reversible posterior leukoencephalopathy syndrome, central pontine myelinolysis, brain abscess, viral meningoencephalitis, transplantation, tacrolimus

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