THE MEANING OF CONTENT OF THE LOW AND MEDIUM MOLECULAR WEIGHT SUBSTANCES IN PATHOGENESIS OF INTOXICATION IN CASE HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

The aim of the study was to clarify the role of low and medium molecular weight substances (L and MMWS) and other endogenous toxins in pathogenesis of hemorrhagic fever with renal syndrome (HFRS).The results are based on data from a prospective study of 124 patients with HFRS. We determined the levels of L and MMWS in plasma, erythrocytes and urine using M.Ya Malakhova method, values of osmolarity of blood serum and urine using cryoscopicmethod.Highest level of L and MMWS in plasma was in the height of the disease for mild condition of 14.9±0,53 c.u., moderate condition of 29.3±3,50 c.u., severe condition 46,6±4,70 c.u. and in erythrocytes during the period of polyuria at the mild condition of 21.2±0,70 c.u., moderate condition of 29.2±1,02 c.u., severe condition 35,6±1,71c.u.The investigation revealed a direct correlation of medium strength level of L and MMWS plasma with values of intestinal toxins, hematological indices of intoxication, nitogen metabolites. L and MMWS in the blood possess osmotic activity, participate in the development of toxicity in HFRS and determine the severity of the disease.