THIETANYLXANTHINES - A PROMISING CLASS OF COMPOUNDS OF PSYCHOPHARMACOLOGICAL ACTION

Abstract

Search of new psychotropic drugs is one of relevant problems of pharmacology. Works of domestic and foreign authors indicate the presence of psychotropic activity in xanthine derivatives. Screening of psychotropic drugs is carried out by studying their influence on behavior of experimental animals. The purpose of the research was studying of action of new thietan-containing xanthine derivatives on individual behavior of white outbred mice in the "open field" test. 25 newly synthesized compounds were investigated. Single injection of substances were made intraperitoneally in two doses (1/10 and 1/100 from molecular weight).It is established that new derivatives of thietanylxanthine change the behavior of animals in the "open field" test. The nature of action depends on chemical structure of the compound. The substances F-34, F-61, F-86, F-102, IA-4, UM-23, F-101, F-147, F-159 have sedative, F-30 - activating and antianxiety, F-45, F-102, F-106 and F-164 - antianxiety action on white outbred mice.