BERBERINE-INDUCED ANTICANCER EFFECTS IN SQUAMOUS CELL CARCINOMA OF ORAL TONGUE CELLS
Аннотация
Squamous cell carcinoma of oral tongue belongs to highly invasive malignancies of head and neck area. The natural isoquinoline alkaloid berberine has demonstrated anti-tumor potential in various cancer types. This research was aimed to study in vitro effects of berberine in squamous cell carcinoma of oral tongue. Berberine reduced the proliferation of CAL-27 cells in a dosedependent manner (IC50 = 36μM). Furthermore, berberine strongly inhibited invasion of squamous cell carcinoma of oral tongue cells (EC50 = 0,9μM). Anti-proliferative and anti-invasive actions displayed by berberine in CAL-27 cell line suggest the in vitro anticancer efficacy of the natural isoquinoline alkaloid.
Об авторах
G. Tuguzbaeva
College of Pharmacy, Harbin Medical University; Bashkir State Medical University
Россия
Россия
Er Yu
College of Pharmacy, Harbin Medical University
Россия
Россия
V. Pavlov
Bashkir State Medical University
Россия
Россия
Niu Yumei
School of Dentistry, The First Affiliated Hospital of Stomatology, Harbin Medical University
Россия
Россия
Bai Yunlong
College of Pharmacy, Harbin Medical University
Россия
Россия
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Рецензия
Для цитирования:
, , , , . Медицинский вестник Башкортостана. 2017;12(6):83-86.
For citation:
Tuguzbaeva G.M., Yu E., Pavlov V.N., Yumei N., Yunlong B. BERBERINE-INDUCED ANTICANCER EFFECTS IN SQUAMOUS CELL CARCINOMA OF ORAL TONGUE CELLS. Bashkortostan Medical Journal. 2017;12(6):83-86. (In Russ.)
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