BERBERINE-INDUCED ANTICANCER EFFECTS IN SQUAMOUS CELL CARCINOMA OF ORAL TONGUE CELLS
Abstract
Squamous cell carcinoma of oral tongue belongs to highly invasive malignancies of head and neck area. The natural isoquinoline alkaloid berberine has demonstrated anti-tumor potential in various cancer types. This research was aimed to study in vitro effects of berberine in squamous cell carcinoma of oral tongue. Berberine reduced the proliferation of CAL-27 cells in a dosedependent manner (IC50 = 36μM). Furthermore, berberine strongly inhibited invasion of squamous cell carcinoma of oral tongue cells (EC50 = 0,9μM). Anti-proliferative and anti-invasive actions displayed by berberine in CAL-27 cell line suggest the in vitro anticancer efficacy of the natural isoquinoline alkaloid.
About the Authors
G. M. Tuguzbaeva
College of Pharmacy, Harbin Medical University; Bashkir State Medical University
Russian Federation
Russian Federation
Er Yu
College of Pharmacy, Harbin Medical University
Russian Federation
Russian Federation
V. N. Pavlov
Bashkir State Medical University
Russian Federation
Russian Federation
Niu Yumei
School of Dentistry, The First Affiliated Hospital of Stomatology, Harbin Medical University
Russian Federation
Russian Federation
Bai Yunlong
College of Pharmacy, Harbin Medical University
Russian Federation
Russian Federation
References
1. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002 // CA Cancer journal for clinicians. 2005. Vol. 55. P. 74-108
2. Argiris A., Karamouzis M.V., Raben D., Ferris R.L. Head and neck cancer // Labcet. 2008. Vol. 371. P. 1695-1709
3. Brennan, J., Boyle, J., Koch, W., Goodman, S., Hruban, R., Eby, Y., Couch, M., Forastiere, A., and Sidransky, D. (1995). Association between cigarette smoking and mutation of the p53 gene in head and neck squamous carcinoma // New England Journal of Medicine. 1995. Vol. 332. P. 712-717
4. Mao L., Hong W.K., Papadimitrakopoulou V.A. Focus on head and neck cancer // Cancer Cell. 2004. Vol. 5. P. 311-316
5. Pereira M, Oliveira D, Landman G and Kowalski L. Histologic subtypes of oral squamous cell carcinoma: prognostic relevance // J Can Dent Assoc. 2007. Vol. 73. P. 339-344
6. Ni W.J., Ding H.H. and Tang L.Q. Berberine as a promising anti-diabetic nephropathy drug: An analysis of its effects and mechanisms // Eur J Pharmacol. 2015. Vol. 760. P. 103-112
7. Tang J., Feng Y., Tsao S., Wang N., Curtain R. and Wang Y. Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations // J Ethnopharmacol. 2009. Vol.126. P. 5-17
8. Lau C.W., Yao X.Q. and Chen Z.Y., Ko W.H. and Huang Y. Cardiovascular actions of berberine // Cardiovasc Drug Rev. 2001. Vol. 19. P. 234-244
9. Ortiz L.M., Lombardi P., Tillhon M. and Scovassi A.I. Berberine, an epiphany against cancer // Molecules. 2014. Vol. 19. P. 12349- 12367
10. Lin C.C., Kao S.T., Chen G.W., Ho H.C. and Chung J-G. Apoptosis of human leukemia HL-60 cells and murine leukemia WEHI-3 cells induced by berberine through the activation of caspase-3 // Anticancer Res. 2006. Vol. 26(1A). P. 227-242
11. Jabbarzadeh Kaboli P., Rahmat A., Ismail P., Ling K.H. Targets and mechanisms of berberine, a natural drug with potential to treat cancer with special focus on breast cancer // Eur. J. Pharmacol. 2014. Vol. 740. P. 584-595
12. Qi H.W., Xin L.Y., Xu X., Ji X.X., Fan L.H. Epithelial-to-mesenchymal transition markers to predict response of Berberine in suppressing lung cancer invasion and metastasis // J Transl Med. 2014. Vol. 12. P. 22
13. Chu Q., Jiang Y., Zhang W., Xu C., Du W., Tuguzbaeva G., Qin Y., Li A., Zhang L., Sun G., Cai Y., Feng Q., Li G., Li Y., Du Z., Bai Y., Yanf B. Pyroptosis is involved in the pathogenesis of human hepatocellular carcinoma // Oncotarget. 2016. Vol.7(51). P.84658-84665
14. Haddad R.I., Shin D.M. Recent advances in head and neck cancer // New England Journal of Medicine. 2008. Vol. 359. P. 1143-1154
15. Pasquinelli A.E. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship // Nature Review Genetics. 2012. Vol.13. P. 271-282
16. Chen J., Wu F.X., Luo H.L., Liu J.J., Luo T., Bai T., Li L.Q., Fan X.H. Berberine upregulates miR-22-3p to suppress hepatocellular carcinoma cell proliferation by targeting Sp1 // Am J Transl Res. 2016. Vol. 8(11). P. 4932-4941
17. Hu H.Y., Li K.P., Wang X.J., Liu Y., Lu Z.G., Dong R.H., Guo H.B., Zhang M.X. Set9, NK-kB, and microRNA-21 mediate berberineinduced apoptosis of human multiple myeloma cells // Acta Pharmacol Sin. 2013. Vol. 34(1). P. 157-166
Review
For citations:
Tuguzbaeva G.M., Yu E., Pavlov V.N., Yumei N., Yunlong B. BERBERINE-INDUCED ANTICANCER EFFECTS IN SQUAMOUS CELL CARCINOMA OF ORAL TONGUE CELLS. Bashkortostan Medical Journal. 2017;12(6):83-86. (In Russ.)
Views:
56
Email this article 
