CIRCULATING MICRORNAS AS NEW POTENTIAL BIOMARKERS FOR EARLY DIAGNOSIS AND PROGNOSIS OF SPONTANEOUS INTRACEREBRAL HEMORRHAGE IN HUMANS
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which play a key role in the regulation of post-transcriptional gene by binding to complementary sites in the 3 'untranslated region of the RNA messengers. In the last decade, their role in human diseases, from oncology to cardiovascular diseases, has been established by a lot of evidence. MicroRNAs are involved in the risk factors for intracerebral hemorrhage, including hypertension and atherosclerosis. Hypertension and atherosclerosis of cerebral vessels are major factors for spontaneous intracerebral hemorrhage as high blood pressure and atherosclerosis may cause the formation of microaneurysms in small cerebral arteries and arterioles, and thus damaging the vascular wall, leading to hemorrhage. Unfortunately, the role of microRNA in the pathophysiology of intracerebral hemorrhage was the subject of more recent studies. Since studies of microRNAs in hemorrhagic stroke is still in its infancy, it is expected that in the next few years there will be a significant discovery that may have important perspectives in clinical work.
About the Authors
I. F. Gareev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
Sh. M. Safin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
Shiguang Zhao
Харбинский медицинский университет
Russian Federation
Russian Federation
Guang Yang
Харбинский медицинский университет
Russian Federation
Russian Federation
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Review
For citations:
Gareev I.F., Safin Sh.M., Zhao Sh., Yang G. CIRCULATING MICRORNAS AS NEW POTENTIAL BIOMARKERS FOR EARLY DIAGNOSIS AND PROGNOSIS OF SPONTANEOUS INTRACEREBRAL HEMORRHAGE IN HUMANS. Bashkortostan Medical Journal. 2017;12(6):120-125. (In Russ.)
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