DYNAMICS OF REGENERATION OF INFECTED CORNEAL DEFECTS WITH THE USE OF VARIOUS METHODS OF TREATMENT

Abstract

At the moment, the number of corneal blindness in the world is growing, which is a great medical and social problem. It is promising to find new means of preventing corneal opacity, as well as to accelerate the rate of corneal regeneration in infected traumas. One of the new ways of treating injuries and burns of the cornea is the use of antibacterial polymeric membranes with immunomodulating effect, the action of which is aimed both at destroying the pathogens of infection in the area of damage and stimulating local immunity. Under the in vivo experiment on the adult rabbits, an infected corneal injury was modeled in three groups. In the control group, treatment was not performed, standard therapy was performed in the comparison group, in the experimental group treatment was performed using antibacterial polymeric membranes with immunomodulating effect. The fastest rates of complete restoration of the integrity of the epithelium of the cornea were revealed in the experimental group. At day 7, the cornea completely regenerated in the comparison group. The use of antibacterial polymeric membranes with immunomodulating effect is a promising method of treatment of infected corneal injuries.