COMPARATIVE EVALUATION OF THE EFFECTIVENESS OF THE INFLUENCE OF ANGIOTENSIN RECEPTORS’ INHIBITORS ON THE ACTIVITY OF THE VASCULAR WALL IN PATIENTS WITH ARTERIAL HYPERTENSION AFTER ОСCLUSION OF RETINAL VESSELS

Abstract

The research was made to study the effect of therapeutic complexes, which included angiotensin receptor inhibitors (valsartan, irbesartan) on the anticoagulant, fibrinolytic and antiaggregational function of the vascular wall in 53 patients with arterial hypertension of the first (I)-second(II) degree, who suffered from an acute pathology of the retinal vessels and optic nerve. Thrombosis of the central retinal vein or its branches was observed in 35 patients (66,0%), the occlusion of the central retinal arteria was observed in 5 patients (9,4%), vascular optic neuropathy was observed in 13 patients (24,6%). It was established, that the use of the therapeutic complex, which includes valsartan, leads to normalization of the vascular wall functions for 4 months of treatment with constant effect up to 12 months of observation. The use of irbesartan in the treatment improves, but does not normalize, the functions of the vascular wall by the 4th month of treatment, and has a tendency to decrease the achieved effect in the future, so the risk of thrombosis is observed in this category of patients.