CHARACTERISTICS OF SOME INDICATORS OF IMMUNE STATUS OF PATIENTS WITH EYE DISEASE IN HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

Data on the study of the immune status of patients with ocular manifestations of hemorrhagic fever with renal syndrome are rare. In this regard, it was interesting to study the immune system of patients with hemorrhagic fever with renal syndrome in the midst of illness and during convalescence. Under observation there were 13 people in the acute phase of the disease (10 men and 3 women, aged 30-59 years old) and 12 people in the stage of convalescence (3 men and 9 women, aged 25-69 years old). Observed patients had moderate and severe forms of hemorrhagic fever with renal syndrome, confirmed by serological studies, with lesions of the eye. The restoration of the immune status of patients undergoing moderate and severe forms, occurs in a long time. In the period of late convalescence the number of Rosette-forming lymphocytes normalized, the frequency of dysgammaglobulinemia significantly decreased, but the average number of CD19+ and natural killer (CD16+) remained significantly higher. At the stage of late convalescence, in addition to the abovementioned changes, functional activity of T-cells remained reduced, and levels of circulating immune complexes remained high.