NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) - A NEW MARKER OF ACUTE KIDNEY INJURY AND PERINATAL ASPHYXIA
Abstract
Perinatal asphyxia is one of the leading reasons of neonatal incidence and mortality, often being followed by the acute renal damage (ARD). So, early and precise assessment of nervous system and other organs damage severity in case of intranatal hypoxia is of particular value. Classical methods of asphyxia and ARD diagnosis have no adequate diagnostic accuracy and a predictive significance in the neonatal period, therefore the possibility of use of kidney injury biochemical markers is actively studied. NGAL is a protein concentration of which considerably increases both in urine, and in blood during the first hours after ARD development, providing a chance for quick diagnosis and administration of necessary therapy. Also, according to the up-to-date, there is a high prognostic potential for development of hypoxic-ischemic injuries of brain. Thus, available data allows to define NGAL as a perspective biochemical marker demanding further studying.
About the Authors
B. A. Konoplev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; Клинический госпиталь «Мать и Дитя»
Russian Federation
Russian Federation
A. V. Alekseev
Клинический госпиталь «Мать и Дитя»
Russian Federation
Russian Federation
R. A. Khashim
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; Клинический госпиталь «Мать и Дитя»
Russian Federation
Russian Federation
References
1. Сувернева, А.А. К вопросу об интранатальной гибели плода / А.А. Сувернева, А.А. Буткеева, Е.Х. Сапахова // Международный журнал прикладных и фундаментальных исследований. - 2014. - № 2. - С.135-137
2. Борщева, А.А. Антенатальная и интранатальная смерть плода. Проблемы и перспективы / А.А. Борщева, Г.М. Перцева // Scien- tific and Practical Journal of Health and Life Sciences. - 2015. - № 4. - С. 68-74
3. Абдуллаева, Ж.О. Перинатальные исходы при патологии пуповины плода / Ж.О. Абдуллаева // Вестник новых медицинских технологий. - 2008. - № 2. - С.52-53
4. Асфиксия новорожденных // Н.П. Шабалов [и др.]. - М.: МЕДпрессинформ, 2003. - 368 с
5. Применение лечебной гипотермии при лечении тяжелой интранатальной асфиксии [Электронный ресурс]/ А.А. Зарубин [и др.] // Universum: медицина и фармакология. - 2015. - № 11 (22). URL: http://cyberleninka.ru/article/n/primenenie-lechebnoy-gipotermii-pri-lechenii-tyazheloy-intranatalnoy-asfiksii
6. Two million intrapartum-related stillbirths and neonatal deaths: where, why, and what can be done? / JE Lawn [et al.] // Int J Gynaecol Obstet. - 2009. - Vol. 107, № 1. - P. 5-18
7. ACOG Committee Opinion No. 348. Umbilical cord blood gas and acid-base analysis. American College of Obstetricians and Gynecologists // ObstetGynecol. - 2006. - Vol. 108, № 13. - Р. 19-22
8. Bax, M. Birth asphyxia: a statement. World Federation of Neurology Group / M Bax, KB. Nelson // Dev Med Child Neurol. - 1993. - № 35(11). - Р. 1022-1024
9. Low, JA. Intrapartum fetal asphyxia: definition, diagnosis, and classification. // Am J Obstet Gynecol. - 1997. - May; 176(5). - Р. 957-959
10. Aslam, S. Biomarkers of multiorgan injury in neonatal encephalopathy / S. Aslam, E.J. Molloy // Biomark Med. - 2015. - Vol. 9(3). - P. 267-75
11. American Academy of Pediatrics and American College of Obstetricians and Gynaecologists. Care of the neonate. Guidelines for perinatal care / Gilstrap LC, Oh W, editors. Elk Grove Village (IL): American Academy of Pediatrics, 2002. - P. 196-197
12. Systematic Review and Quality Appraisal of International Guidelines on Perinatal Care of Extremely Premature Infants / N. Binepal [et al.] // CurrPediatr Rev. - 2015. - Vol. 11, № 2. - P. 126-134
13. Haider, B.A. Birth Asphyxia in Developing Countries: Current Status and Public Health Implications /B.A. Haider, Z.A. Bhutta // CurrProblPediatrAdolesc Heal. Care. - 2006. - Vol. 1. № June. - P. 178-188
14. Ahearne, C. Short and long term prognosis in perinatal asphyxia: An update / C. Ahearne, G. Boylan, D. Murray // World J ClinPediatr. - 2016. - Vol. 5, № 1. - P. 67-74
15. Perveen, F. Umbilical Cord Blood pH in Intrapartum Hypoxia / F. Perveen, A. Khan, T. Ali // J Coll Physicians Surg Pak. - 2015. - V. 25, № 9. - P. 667-670
16. Intrapartum asphyxia: Risk factors and short-term consequences / JP Bouiller [et al.] // J GynecolObstetBiolReprod (Paris). - 2015, Aug 27. pii: S0368-2315(15)00169-6
17. The mechanisms and treatment of asphyxial encephalopathy / G Wassink [et al.] // Front Neurosci. - 2014, Feb 27. - P. 8-40
18. Aslam S, Molloy EJ. Biomarkers of multiorgan injury in neonatal encephalopathy / S. Aslam, EJ. Molloy // Biomark Med. - 2015. - Vol. 9(3). - P. 267-275
19. Neonatal brain injury as a consequence of insufficient cerebral oxygenation / K. Placha [et al.] // NeuroEndocrinol Lett. - 2016. - Vol. 37(2). - P. 79-96
20. Multiorgan dysfunction in infants with post-asphyxial hypoxic-ischaemic encephalopathy / P. Shah [et al.] // Archives of Diseases in Childhood. Fetal and Neonatal Edition. - 2004. - Vol. 89. - P. 152-155
21. Evaluation of renal functions in asphyxiated newborns / A. Aggarwal [et al.] // J Trop Pediatr. - 2005. - Oct; 51(5). - P. 295-299
22. Effects of hypothermia forperinatal asphyxia on childhood outcomes / D. Azzopardi [et al.]// N Engl J Med. - 2014. - Jul 10, Vol. 371(2). - P. 140-149
23. Time is brain: starting therapeutic hypothermia within threehours after birth improves motor outcome in asphyxiated newborns / M. Thoresen [et al.] // Neonatology. - 2013. - Vol. 104(3). - P. 228-233
24. Essajee, F. Urine neutrophil gelatinase-associated lipocalin in asphyxiated neonates: a prospective cohort study / F Essajee, F Were, B. Admani // PediatrNephrol. - 2015. - Jul, Vol. 30(7). - P. 1189-1196
25. Evaluation ofglomerular and tubular renal function in neonates with birth asphyxia / S Kaur [et al.] // Ann TropPaediatr. - 2011. - Vol. 31(2). - P. 129-134
26. Neonatal Acute Kidney Injury / DT Selewski [et al.]// Pediatrics. - 2015, Aug;136(2). - P. 463-473
27. Jetton, J.G. Update on acute kidney injury in the neonate / J.G. Jetton, D.J. Askenazi // Curr. Opin. Pediatr. - 2012. - Vol. 24, № 2. - P. 191-196
28. Sweetman, D.U. Management of renal dysfunction following term perinatal hypoxia-ischaemia / D.U. Sweetman, M. Riordan, E.J. Molloy // ActaPaediatr. - 2013. - Mar, Vol. 102(3). - P. 233-241
29. Mortazavi F. Acute kidney failure in neonatal period / F. Mortazavi, S. HosseinpourSakha, N. Nejati // Iran J Kidney Dis. - 2009. - Jul; 3(3). - P. 136-140
30. Evaluation of renal functions in asphyxiated newborns / A. Aggarwal [et al.] // J Trop Pediatr. - 2005. - Oct; 51(5). - P. 295-299
31. Urinary neutrophilgelatinase-associated lipocalin as an early biomarker for prediction of acutekidney injury in preterm infants / Y. Tabel [et al.] // Am J Perinatol. - 2014. - Feb; 31(2). - P.167-174
32. Borregaard, N. Neutrophil gelatinase-associated lipocalin, a siderophore-binding eukaryotic protein / N. Borregaard, J.B. Cowland // Biometals. - 2006. - Vol. 19, № 2. - P. 211-215
33. Xu S. Lipocalins as biochemical markers of disease / S. Xu, P. Venge // Biochim. Biophys. Acta. - 2000. - Vol. 1482, № 1-2. - P. 298-307
34. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake / L.R. Devireddy [et al.] // Cell. - 2005. - Vol. 123, № 7. - P. 1293-305
35. Neutrophil gelatinase-associated lipocalin-mediated iron traffic in kidney epithelia / K.M. Schmidt-Ott [et al.] // Curr. Opin. Nephrol. Hypertens. - 2006. - Vol. 15, № 4. - P. 442-449
36. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury / K. Mori [et al.] // J. Clin. Invest. - 2005. - Vol. 115, № 3. - P. 610-621
37. The local and systemic inflammatory transcriptome after acute kidney injury / Grigoryev D.N. [et al.]// J. Am. Soc. Nephrol. - 2008. - Vol. 19, № 3. - P. 547-558
38. Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants / Parravicini E. [et al.] // Pediatr. Res. - 2010. - Vol. 67, № 6. - P. 636-640
39. Serum and urine acute kidney injury biomarkers in asphyxiated neonates / K. Sarafidis [et al.] // Pediatr. Nephrol. - 2012. - Vol. 27, № 9. - P. 1575-1582
40. Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage / D. Bolignano [et al.] // Am J Kidney Dis. - 2008. - Vol. 52, № 3. - P. 595-605
41. Urinary neutrophil gelatinase-associated lipocalin is a promising biomarker for late onset culture-positive sepsis in very low birth weight infants / E. Parravicini [et al.] // Pediatr. Res. - 2010. - Vol. 67, № 6. - P. 636-640
42. Ahmed, N. Acute renal failure: nephrosonographic findings in asphyxiated neonates / N Ahmed, J Chowdhary, RU. Saif // Saudi J Kidney Dis Transpl. - 2011. - Nov; 22(6). - P. 1187-1192
43. Factors limiting usefulness of serum and urinary NGAL as a marker of acute kidney injury in preterm newborns / A. Suchojad [et al.] // Ren Fail. - 2015. - Vol. 37, № 3. - P. 439-445
44. Neutrophil gelatinase-associated lipocalin: ready for routine clinical use? An international perspective / C. Ronco [et al.]// Blood Purif. - 2014. - Vol. 37, № 4. - P. 271-285
45. Detection of acute kidney injury in premature asphyxiated neonates by serum neutrophil gelatinase-associated lipocalin (sNGAL)- sensitivity and specificity of a potential new biomarker / B. Pejović [et al.] // Biochem. Medica - 2015. - Vol. 25, № 3. - P. 450-459
Review
For citations:
Konoplev B.A., Alekseev A.V., Khashim R.A. NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) - A NEW MARKER OF ACUTE KIDNEY INJURY AND PERINATAL ASPHYXIA. Bashkortostan Medical Journal. 2017;12(1):93-99. (In Russ.)
Views:
82
Email this article 
