DYNAMICS OF THE LEVEL OF SERUM CYTOKINE IN CHILDREN WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

The article presents the results of analysis of serum cytokines level in children with HFRS. The study was conducted in 47 children aged 5-17, 25 of them had HFRS of medium-severe form, 22 - HFRS of severe form. Control group included 24 healthy children aged 5-17 years old. The content of cytokines IL-1β TNFα INFα INF-γ IL-10 in patients was studied in febrile, oliguric, polyuric periods and in the period of convalescence, 1 month after discharge from the hospital.It was determined, that HFRS children show an increase in content of anti-inflammatory cytokines IL-1β and ТNFα at the beginning of febrile period. The highest point of these cytokines is noted during oliguric period. INFα and INF-γ levels decrease and are the lowest at oliguric period in case of severe HFRS. Concentration of anti-inflammatory cytokine IL-10 during febrile period has a tendency to increase, significantly important increase is noted during oliguric period and keeps increasing at polyuric period.