METHODS OF OBTAINING INDUCED PLURIPOTENT STEM CELLS
Abstract
Тhe fundamental task of regenerative medicine is the renewal or replacement of tissues and organs by recipient biocompatible implants. Pluripotent stem cells have the capacity for endless self-renewal and differentiation into more than 200 types of adult cells of human body. In the field of biomedicine, the introduction of induced pluripotent stem cells (IPSC) seems to be the most strategically advantageous, because their sources are relatively available, enabling to effectively produce and cultivate tissues in vitro. Reprogramming of somatic cells leads to their regression to the original pluripotent state. Independent groups of scientists have proposed a variety of ways to improve the induction of pluripotency, in order to limit immunogenicity, oncogenecity and to increase efficiency and speed up the kinetics of the process. In this review, we have analyzed a variety of approaches for obtaining IPSC and identified the most promising trends in the development of this direction.
About the Authors
T. I. Bikkuzin
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
V. N. Pavlov
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
I. F. Gareev
ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Bikkuzin T.I., Pavlov V.N., Gareev I.F. METHODS OF OBTAINING INDUCED PLURIPOTENT STEM CELLS. Bashkortostan Medical Journal. 2018;13(2):91-96. (In Russ.)
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