PROMISING ANTIDEPRESSANT AMONG XANTINE DERIVATIVES

Abstract

The paper presents the results of the study of acute toxicity and antidepressant activity of hydrazide of 2-[1,3-dimethyl-7- (tiethanil-3) xanthinyl-8-thio]acetic acid with a single and long-term administration in a wide dose range. The experiments were performed on white outbred mice. A singly studied compound was tested at doses of 35 mg / kg, 23 mg / kg, 12 mg / kg, 5.4 mg / kg,3.7 mg / kg, 1.95 mg / kg and 0.97 mg / kg. In chronic administration, the compound was administered at the lowest effective dose(0.97 mg / kg) during 14 days. It was found that hydrazide of 2- [1,3-dimethyl-7-(tiethanil-3)xanthinyl-8-thio]acetic acid belongs to the class of low-toxic compounds. In the tests, "tail suspension" and "forced swimming" showed that the most pronounced antide- pressant effect of the compound is after a single dose of 5.4 mg / kg, reducing the ID by 61% compared with the control. In chronic administration at a dose of 0.97 mg / kg, 2-[1,3-dimethyl-7-(tiethanil-3)xanthinyl-8-thio]acetic acid hydrazide has an antidepressant effect comparable to that of the comparative preparation fluoxetine. In the "open field" test, the compound under study with a single and prolonged intraperitoneal injection does not affect the motor and orienting-research activity and emotional anxiety of mice.