OBTAINING AND INVESTIGATION OF BIOLOGICAL ACTIVITY OF SUBSTITUTED HYDRAZIDES-NH-2-METOXYBENZOYL-5-IODANTRANYLIC ACID

Abstract

Derivatives of аnthranilic acid, which became known as representatives of a wide range of pharmacological activities, are an interesting and promising class of compounds in the field of synthesis.R-benzylidenhydrazides were obtained by the reaction of condensation of hydrazide NH-2-methoxybenzoyl-5-iodoаnthranilic acid with aromatic aldehydes in the ethanol medium in the presence of hydrochloric acid under stirring for 1 hour at a temperature of 18-20°C. Purity of the obtained products was controlled by TLC. The structure of the compounds was confirmed by 1H NMR spectroscopy.Antimicrobial and antifungal activities were investigated in the obtained new compounds. According to results of the study, the obtained substances exhibit a depressing effect on the growth of bacterial and fungal cultures in a concentration of 1000 mcg/ml.