THE ROLE OF Β2-ADRENERGIC RECEPTOR GENE (ADRB2) POLYMORPHISMS IN ASTHMA
Abstract
Asthma is a common multifactorial respiratory disease. Asthma develops by the interaction of hereditary predisposition, environmental factors and epigenetic changes. Sensitivity of patients to anti-asthmatic drugs is by 60-80% due to genetic factors. The article provides an overview of the effect of β2-adrenergic receptor gene polymorphisms in asthma development and the efficiency of asthma treatment. β2-adrenergic receptor plays an important role in the contractility of the respiratory tract. It is a target for β2-agonists having bronchodilative and bronchoprotective effects. Candidate, associative, pharmacogenetics, whole-genome and epigenetics studies results devoted to the study of the ADRB2 gene are analyzed.
About the Authors
O. N. Savelieva
ФГБОУ ВО «Башкирский государственный университет»
Russian Federation
Russian Federation
A. S. Karunas
ФГБОУ ВО «Башкирский государственный университет»; Институт биохимии и генетики УФИЦ РАН
Russian Federation
Russian Federation
Yu. Yu. Fedorova
Институт биохимии и генетики УФИЦ РАН
Russian Federation
Russian Federation
E. K. Khusnutdinova
Институт биохимии и генетики УФИЦ РАН
Russian Federation
Russian Federation
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For citations:
Savelieva O.N., Karunas A.S., Fedorova Yu.Yu., Khusnutdinova E.K. THE ROLE OF Β2-ADRENERGIC RECEPTOR GENE (ADRB2) POLYMORPHISMS IN ASTHMA. Bashkortostan Medical Journal. 2018;13(5):69-75. (In Russ.)
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