PRE-IMPLANTATION GENETIC DIAGNOSIS AS A KEY PARAMETER FOR THE SUCCESS OF IN VITRO FERTILIZATION
Abstract
The paper presents the results of a retrospective analysis of 150 females, who have undergone IVF and embryo transfer with preimplantation genetic diagnosis (PGD) in Central Clinic of Baku during 2010-2017. The aim of the study was to study the frequency of occurrence of the structure of chromosomal abnormalities on the basis of PGD of embryos in the program of IVF, as well as the effect of this procedure on the results of pregnancies. It was revealed that the highest frequency of chromosomal aberrations was observed in the group with miscarriage, with idiopathic infertility and several unsuccessful attempts of IVF in the anamnesis. Clinical pregnancy was observed in 48.9% of cases with the transfer of normal embryos, and the birth of a healthy child - in 40.8% of cases. The study of the frequency of chromosomal pathologies in groups of women with various causes of infertility showed that changes in the 15th pair of chromosomes were significantly more frequent in women of all four groups, 46.45% in the 1st group, 24.59% in the 2nd group, 13,66% in the 3rd group and 10.9% in the 4th group, compared with women in the control group - 4.37%, p <0.05-0.001. In the 16th pair of chromosomes, the changes were established for women of the 1st, 2nd and 3rd groups, compared to women in the control group, p <0.05-0.01.
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Review
For citations:
Ismayilova M.K. PRE-IMPLANTATION GENETIC DIAGNOSIS AS A KEY PARAMETER FOR THE SUCCESS OF IN VITRO FERTILIZATION. Bashkortostan Medical Journal. 2018;13(6):28-33. (In Russ.)
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