EVALUATION OF LIPID PROFILE IN PATIENTS WITH OBESITY AND GESTATIONAL DIABETES MELLITUS

Abstract

The article presents the results of the analysis of the lipid profile in the first and third trimesters of pregnancy in patients with GDM (gestational diabetes mellitus) and in pregnant women with different degrees of obesity. The study included 182 women. Serum levels of total cholesterol (TC), triglycerides (TG), low density lipoproteins (LDL), very low density lipoproteins (VLDL), high density lipoproteins (HDL) were evaluated. Atherogenic coefficient (AC) was calculated. In all patients the concentration of cholesterol increased significantly with the gestational age (p <0.05), however, in patients with obesity, the initial high level of cholesterol was noted with a further moderate increase by the third trimester. The lowest level of cholesterol is noted in the group of pregnant women with GDM in both the first and the third trimester. In the first trimester of pregnancy in obese pregnant women an increased level of cholesterol (more than 5.2 mmol / l) is significantly more common: I degree is 14, with II - 16 and III-17 (40%, 36% and54%, respectively). No significant difference was found in LDL-levels in patients with I and III degree of obesity, however, in pregnant women with II degree of obesity and GDM the level of LDL in the third trimester was significantly higher (p <0.05).