INFLUENCE OF NEW 7-THIETANIL-8-PIPERAZINOXANTHINES AND SALICYLATES ON HEMOSTASIS SYSTEM IN HEALTHY ANIMALS AND UNDER CONDITIONS OF EXPERIMENTAL THROMBOSIS

Abstract

Potentially high frequency of thrombosis determines the need to find and develop new means to correct hemostasis system. This article shows the findings of antiaggregatory activity of newly synthesized derivatives of 7-thietanil-8-piperazinoxanthines and new salicylates with aminoacids regarding functional activity of platelets during intravenous injection in rats and assessment of efficiency of their preventive application under conditions of carotid thrombosis.The findings show that the most antiaggregatory activity in rats is expressed during intravenous injection of a compound with the lab name code 'la', which is a piperazin-containing xanthine by its chemical structure. This compound also shows high potential as a means to prevent carotid thrombosis in rats.Thus, there is a ground to prove the prospects to search for potential antiplateletes among derivatives of these kind and to give reasons to choose the most active compound for preclinical research.