THE EFFECT OF ISCHEMIC CONDITIONING ON THE CONTRACTILE FUNCTION OF THE MYOCARDIUM IN ISCHEMIC AND REPERFUSION MYOCARDIAL INJURY

Abstract

The article presents a literature review on ischemic conditioning and its influence on myocardial contractile function in ischemia/reperfusion. Ischemic conditioning causes cardioprotection; the final size of the infarction zone after myocardial ischemia is much smaller. However, whether ischemic conditioning has a beneficial effect on myocardial contractility after ischemia/reperfusion remains unknown. To date, ex vivo studies have shown that ischemic conditioning improves contractile recovery of isolated ventricular papillary muscle or atrial trabecula after simulated ischemia. Nevertheless, as it was found, the results of animal studies do not match the results of studies on patients undergoing elective heart surgery, and ultimately are contradictory. Ischemic conditioning at the subcellular level improves energy metabolism, preserves mitochondrial respiration, adenosine triphosphate (ATP) production, and Ca2+ homeostasis in isolated myocardial mitochondria. Ischemic conditioning represents a post-translational modification of proteins of the contractile apparatus of the myocardium. However, the long-term results and positive effects of ischemic conditioning on myocardial contractile function are doubtful today and need further study.