EFFECT OF ANTIGESTAGENIC THERAPY OF UTERINE FIBROIDS ON THE STATE OF OVARIAN RESERVE

The objective: to assess the effect of antigestagenic therapy of uterine myoma on ovarian reserve in the patients of reproductive age. Due to the increasing incidence of uterine myoma among women of young reproductive age, conservative treatment modalitiesfor this pathology are becoming relevant. However, the proportion of surgical interventions for uterine myoma remains high. Thepreservation of the ovarian reserve in patients of fertile age remains an important issue to be considered. In our study, we evaluated the effect of antigestagen therapy on the condition of the ovarian reserve. The indicators of the ovarian reserve among women of three groups before and after treatment were analyzed. Group 1 (n = 38) received surgical treatment in the form of laparoscopic conservative myomectomy without subsequent anti-relapse drug therapy; Group 2 (n = 43) received surgical treatment in the form laparoscopic conservative myomectomy followed by anti-relapse drug therapy including mifepristone at a dose of 50 mg daily from the2nd day of the menstrual cycle for 3 months; Group 3 (n = 36) received drug monotherapy including mifepristone at a dose of 50mg daily from the 2nd day of the menstrual cycle for 3 months. According to the results of the study, the indicators of the ovarian reserve in the group of drug treatment with antigestagens remained the same, in the groups receiving surgical treatment (1 and 2), a deterioration was recorded. Thus, the mifepristone drug does not adversely affect the condition of the ovarian reserve in women of reproductive age.

антигестагены, миома, миомэктомия, мифепристон, овариальный резерв, antigestagens, myoma, myomectomy, mifepristone, ovarian reserve