CLINICAL AND MORPHOLOGICAL PARALLELS OF INTERNAL ORGANS DAMAGE IN HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

The aim of the work is to study the clinical state of the lungs and heart in patients with hemorrhagic fever with renal syndrome(HFRS) and to compare it with the data of pathomorphological studies of those who died from HFRS. Material and methods. The study involved clinical examination of 220 patients with HFRS (physical, laboratory, serological methods, pulse oximetry, electrocardiography, chest x-ray), determination of troponin I in 24 patients in dynamics and analysis of19 pathological conclusions of those who died from HFRS . Results. The main clinical and diagnostic and pathomorphological characteristics of lung and heart lesions in HFRS depending on the form of the disease were revealed: cough, shortness of breath, pulmonary infiltration, pleural effusion, acute respiratory distress syndrome, interstitial and alveolar edema, dystelectases of the lung parenchyma, hyaline membranes in the lumen of the alveo-li; signs of overload of the right heart, violations of repolarization on ECG, in isolated cases - increase in troponin I, granular dys-trophy of cardiomyocytes, small foci of myocardial necrosis, myocarditis.Conclusion. The study established the dependence of lung and heart lesions on the form of the disease, their clinical and morphological characteristics.