HOMOCYSTEINE AS A MARKER OF ACUTE KIDNEY INJURY AND ENDOTHELIAL DISFUNCTION IN PATIENTS WITH HEMORRHAGIC FEVER WITH RENAL SYNDROME

Abstract

The purpose of the work is to determine the changes of homocysteine blood level in patients with HFRS of varying severity in the dynamics of the disease in order to evaluate the necessity of homocysteine correcting treatment. Material and methods. 93 male patients with HFRS of various severity (aged 18-50) were observed. To reduce the blood level of homocysteine, the composition of vitamins «Angiovit®» was used.Results. The study showed that in HFRS of various severity (moderate, severe and severe with complications) the blood homocysteine level significantly increased with the peak observed in oliguric period. The strong correlations between blood levels of homocysteine and thrombomodulin, homocysteine and cystatin C were found. The used vitamin composition reduced the level of homocysteine in the blood and duration of oliguria. Conclusion. Increased homocysteine level in patients with HFRS, depending on the severity and period of the disease, was revealed. The prognostic significance of homocysteine as an early marker of endothelial dysfunction and acute kidney injury in HFRS was established. The use of vitamin composition «Angiovit®» in combination with standard therapy for HFRS can reduce the duration and degree of oliguria.