THE INFLUENCE OF STRONTIUM RANELATE ON BONE MINERAL DENSITY IN MEN WITH BRONCHIAL ASTHMA IN COMBINATION WITH OSTEOPOROSIS

Abstract

Objective: to evaluate the influence of strontium ranelate on bone mineral density (BMD) of the lumbar spine and femoral neck in men with bronchial asthma (BA) in combination with osteoporosis (OP).Material and methods: the study was performed in 2016-2017. 39 men aged 51 to 70 were included in an open controlled non-randomized prospective observational one-year study. The main group consisted of 27 male patients with bronchial asthma combined with osteoporosis; the control group consisted of 12 almost healthy men.Results. The average age of patients with BA in combination with OP was 64.6±1.2; the duration of BA was 20.1±9.8 years. Pa-tients with BA in combination with OP received basic therapy of BA, strontium ranelate, calcium and vitamin D. 12 months of treatment showed a significant increase in BMD in the lumbar spine by 6.6% and femoral neck by 1.9%. During the follow-up, the number of patients with back pain decreased from 57 to 35%, which is probably due to increased daily activity and exercise therapy, since the examined patients did not use non-steroidal anti-inflammatory drugs. So, 55.56% of men rated daily activity as excellent or good after six months of treatment, and after a year - 66.67% of patients.